CAJ | 학술논문

探讨CD4＋ T h细胞因子对孕激素治疗先兆流产的影响。方法随机抽取深圳市妇幼保健院2010年7月至2011年2月收治的60例先兆流产患者的临床资料进行回顾性分析，本组所有患者均采用孕激素治疗，同时采用酶联免疫吸附试验对先兆流产患者使用孕激素治疗前、后血清中的CD4＋ T h细胞因子进行测定，深入探讨CD4＋ T h细胞因子对孕激素治疗先兆流产的影响；并且与同期60例先兆流产妇女未治疗患者和60例正常早孕者的临床资料进行对比评价。结果经检测发现，孕激素治疗先兆流产患者前、后女性 T h1/T h2细胞因子平衡性会有变化，由先兆流产时平衡趋向 T h1的方向致使用孕激素治疗后平衡趋向 T h2的方向变化，并且各组细胞CD4＋ Th细胞因子均有不同，其中正常妊娠妇女白细胞介素-2（IL-2）、IL-4、IL-10和干扰素-α（TNF-α）分别为（92．78±7．86）、（62．78±7．86）、（144．78±7．86）和（102．78±7．86）ng/L ，与先兆流产未治疗组妇女的（223．78±7．86）、（23．78±7．86）、（154．78±7．86）和（26．78±7．86）ng/L ，以及孕激素治疗先兆流产组的（93．78±7．86）、（63．78±7．86）、（52．78±8．33）和（103．78±7．86）ng/L比较，差异有统计学意义（P＜0．05）。结论在先兆流产妇女的血清学检查中，T h1型细胞因子如：T N F-a、IL-2活性较正常妊娠女性明显增高，而 T h2型细胞因子如：IL-10、IL-4活性较正常妊娠女性基本正常或略降低。
탐토CD4＋ T h세포인자대잉격소치료선조유산적영향。방법수궤추취심수시부유보건원2010년7월지2011년2월수치적60례선조유산환자적림상자료진행회고성분석，본조소유환자균채용잉격소치료，동시채용매련면역흡부시험대선조유산환자사용잉격소치료전、후혈청중적CD4＋ T h세포인자진행측정，심입탐토CD4＋ T h세포인자대잉격소치료선조유산적영향；병차여동기60례선조유산부녀미치료환자화60례정상조잉자적림상자료진행대비평개。결과경검측발현，잉격소치료선조유산환자전、후녀성 T h1/T h2세포인자평형성회유변화，유선조유산시평형추향 T h1적방향치사용잉격소치료후평형추향 T h2적방향변화，병차각조세포CD4＋ Th세포인자균유불동，기중정상임신부녀백세포개소-2（IL-2）、IL-4、IL-10화간우소-α（TNF-α）분별위（92．78±7．86）、（62．78±7．86）、（144．78±7．86）화（102．78±7．86）ng/L ，여선조유산미치료조부녀적（223．78±7．86）、（23．78±7．86）、（154．78±7．86）화（26．78±7．86）ng/L ，이급잉격소치료선조유산조적（93．78±7．86）、（63．78±7．86）、（52．78±8．33）화（103．78±7．86）ng/L비교，차이유통계학의의（P＜0．05）。결론재선조유산부녀적혈청학검사중，T h1형세포인자여：T N F-a、IL-2활성교정상임신녀성명현증고，이 T h2형세포인자여：IL-10、IL-4활성교정상임신녀성기본정상혹략강저。
Objective To investigate the influence of CD4+ Th cytokines on treatment effects of progesterone in threatened abortion .Methods Clinical data were randomly selected and retrospectively analyzed in 60 patients with threatened abortion during July 2010 and February 2011 .All patients were treated with progestogen ,and en‐zyme‐linked immunosorbent assay were performed to detect serum CD4+ Th cytokines before and after treatment .A total of 60 patients with untreated threatened abortion and 60 cases of normal pregnancy were also enrolled . Results In patients with threatened abortion ,Th1/Th2 cytokine balance could be changed after progesterone thera‐py .In cases of normal pregnancy ,levels of interleukin (IL‐2) ,IL‐4 ,IL‐10 and interferon (IFN )‐α were (92 .78 ± 7 .86) ,(62 .78 ± 7 .86) ,(144 .78 ± 7 .86) and (102 .78 ± 7 .86)ng/L ,respectively ,which were statistically different with the (223 .78 ± 7 .86) ,(23 .78 ± 7 .86) ,(154 .78 ± 7 .86) and (26 .78 ± 7 .86) ng/L in patients with untreated threatened abortion ,and (93 .78 ± 7 .86) ,(63 .78 ± 7 .86) ,(52 .78 ± 8 .33) and (103 .78 ± 7 .86)ng/L in patients with threatened abortion after treatment (P<0 .05) .Conclusion Activity levels of Th1 cytokines ,including IFN‐a and IL‐2 ,in patients with threatened abortion could be higher ,but those of Th2 cytokines ,including IL‐10 and IL‐4 ,could be as the same level or lower ,compared with cases with normal pregnancy .