CAJ | 학술논문

目的：探讨老年系统性红斑狼疮（SLE）合并冠心病患者的临床特征。方法入选SLE合并冠心病的老年患者30例作为观察组，同期单纯冠心病老年患者30例作为对照组，对比两组患者的基本特征、生化指标、危险因素、心血管病变等。结果观察组男性患者10例、高脂血症病史者3例、吸烟史者3例和危险个数（1．2±1．2）例，均显著少于对照组19例、13例、15例、（2．6±1．3）例，差异均有统计学意义（ P＜0．05），女性患者显著多于对照组，体质量指数显著低于对照组，差异有统计学意义（P＜0．05）；两组患者血脂水平、尿素氮和血肌酐差异均无统计学意义（P＞0．05），但观察组肝功能指标明显高于对照组，差异有统计学意义（P＜0．05）；观察组主要以三支血管病变为主，单支血管病变者显著低于对照组，三支血管病变者显著高于对照组，差异有统计学意义（P＜0．05）。结论老年SLE 合并冠心病好发于女性，危险因素个数较少，肝功能差，冠状动脉病变严重。
목적：탐토노년계통성홍반랑창（SLE）합병관심병환자적림상특정。방법입선SLE합병관심병적노년환자30례작위관찰조，동기단순관심병노년환자30례작위대조조，대비량조환자적기본특정、생화지표、위험인소、심혈관병변등。결과관찰조남성환자10례、고지혈증병사자3례、흡연사자3례화위험개수（1．2±1．2）례，균현저소우대조조19례、13례、15례、（2．6±1．3）례，차이균유통계학의의（ P＜0．05），녀성환자현저다우대조조，체질량지수현저저우대조조，차이유통계학의의（P＜0．05）；량조환자혈지수평、뇨소담화혈기항차이균무통계학의의（P＞0．05），단관찰조간공능지표명현고우대조조，차이유통계학의의（P＜0．05）；관찰조주요이삼지혈관병변위주，단지혈관병변자현저저우대조조，삼지혈관병변자현저고우대조조，차이유통계학의의（P＜0．05）。결론노년SLE 합병관심병호발우녀성，위험인소개수교소，간공능차，관상동맥병변엄중。
Objective To analyze the clinical characteristics of systemic lupus erythematosus (SLE) complicat-ed with coronary heart disease (CHD) in elderly patients .Methods A total of 30 elderly patients combined with SLE and CHD were enrolled as observation group ,and 30 elderly patients with CHD were enrolled as control group .Basic characteristics ,biochemical indexes ,risk factors ,cardiovascular disease and so on were compared between the two groups .Results In observation group ,there were 10 cases of male patient ,3 cases with hyperlipidemia history ,3 ca-ses with smoking history and the dangerous number was (1 .2 ± 1 .2) cases ,which were significantly less than the 19 cases ,13 cases ,15 cases and (2 .6 ± 1 .3) cases of control group respectively (P<0 .05) ,the proportion of female pa-tients was significantly higher than control group ,but body mass index was significantly lower than control group (P<0 .05) .The differences of levels of blood lipid ,urea nitrogen and creatinine were not significant (P>0 .05) ,but levels of liver function indexes in observation group was significantly higher than control group (P<0 .05) .Propor-tion of patients with three lesions in observation group was significantly higher than control group (P<0 .05) .Con-clusion Elderly SLE complicated with CHD might occur mainly in females ,with less numbers of risk factors ,poor liver function and severe pathological changes of coronary artery .