检验医学与临床
檢驗醫學與臨床
검험의학여림상
JOURNAL OF LABORATORY MEDICINE AND CLINICAL SCIENCES
2014年
14期
1916-1917,1920
,共3页
病毒性心肌炎%腹痛%氨基末端脑利钠肽前体%心肌肌钙蛋白I%肌酸激酶同工酶
病毒性心肌炎%腹痛%氨基末耑腦利鈉肽前體%心肌肌鈣蛋白I%肌痠激酶同工酶
병독성심기염%복통%안기말단뇌리납태전체%심기기개단백I%기산격매동공매
viral myocarditis%abdominal pain%N-terminal pro-brain nitric peptide%cardiac troponin I%creatine rinase isoenzyme
目的：探讨氨基末端脑利钠肽前体（NT-proBNP）、心肌肌钙蛋白I（cTnI）、肌酸激酶同工酶（CK-MB）3项生化指标在诊断以腹痛为突出表现的小儿病毒性心肌炎（VMC）中的临床意义。方法选择7例腹痛VMC患儿、33例以腹痛为突出表现同时有循环不稳定表现的非VMC患儿、40例健康儿童，测定其血清NT-proBNP、cTnI、CK-MB水平。结果腹痛VMC组NT-proBNP、cTnI及CK-MB水平明显高于腹痛非VMC组和健康对照组，差异有统计学意义（P＜0．01）。腹痛VMC组与健康对照组CK-MB水平差异有统计学意义（P＜0．01）。腹痛VMC患儿NT-proBNP灵敏度为100．00％，特异性为90．90％；cTnI灵敏度为71．40％，特异性为84．80％；CK-MB灵敏度为57．14％，特异性为39．40％。结论血清NT-proBNP、cTnI、CK-MB是诊断以腹痛为突出表现的 VMC患儿的敏感指标。
目的：探討氨基末耑腦利鈉肽前體（NT-proBNP）、心肌肌鈣蛋白I（cTnI）、肌痠激酶同工酶（CK-MB）3項生化指標在診斷以腹痛為突齣錶現的小兒病毒性心肌炎（VMC）中的臨床意義。方法選擇7例腹痛VMC患兒、33例以腹痛為突齣錶現同時有循環不穩定錶現的非VMC患兒、40例健康兒童，測定其血清NT-proBNP、cTnI、CK-MB水平。結果腹痛VMC組NT-proBNP、cTnI及CK-MB水平明顯高于腹痛非VMC組和健康對照組，差異有統計學意義（P＜0．01）。腹痛VMC組與健康對照組CK-MB水平差異有統計學意義（P＜0．01）。腹痛VMC患兒NT-proBNP靈敏度為100．00％，特異性為90．90％；cTnI靈敏度為71．40％，特異性為84．80％；CK-MB靈敏度為57．14％，特異性為39．40％。結論血清NT-proBNP、cTnI、CK-MB是診斷以腹痛為突齣錶現的 VMC患兒的敏感指標。
목적：탐토안기말단뇌리납태전체（NT-proBNP）、심기기개단백I（cTnI）、기산격매동공매（CK-MB）3항생화지표재진단이복통위돌출표현적소인병독성심기염（VMC）중적림상의의。방법선택7례복통VMC환인、33례이복통위돌출표현동시유순배불은정표현적비VMC환인、40례건강인동，측정기혈청NT-proBNP、cTnI、CK-MB수평。결과복통VMC조NT-proBNP、cTnI급CK-MB수평명현고우복통비VMC조화건강대조조，차이유통계학의의（P＜0．01）。복통VMC조여건강대조조CK-MB수평차이유통계학의의（P＜0．01）。복통VMC환인NT-proBNP령민도위100．00％，특이성위90．90％；cTnI령민도위71．40％，특이성위84．80％；CK-MB령민도위57．14％，특이성위39．40％。결론혈청NT-proBNP、cTnI、CK-MB시진단이복통위돌출표현적 VMC환인적민감지표。
Objective To explore the clinical significance of N-terminal pro-brain nitric peptide (NT-proB-NP) ,cardiac troponin I (cTnI) and isoenzyme of creatinkinase (CK-MB) in the diagnosis of viral myocarditis (VMC) in children with main symptoms of abdominal pain .Methods A total of 7 children with VMC and abdominal (VMC group) ,33 children without VMC but with symptoms of abdominal pain and unstable blood circulation (non-VMC group) ,and 40 healthy children (control group) were enrolled and detected for serum levels of NT-proBNP ,cTnI and CK-MB .Results Serum levels of NT-proBNP ,cTnI and CK-MB in VMC group were higher than non-VMC group and control group (P<0 .01) .Serum level of CK-MB in non-VMc group was higher than control group (P<0 .01) . The sensitivity and specificity of NT-proBNP for the diagnosis of VMC were 100 .0% and 90 .90% ,of cTnI were 71 .40% and 84 .80% ,and of CK-MB were 57 .14% and 39 .40% .Conclusion Serum NT-proBNP ,cTnI and CK-MB might be sensitive indicators for the diagnosis of VMC in children with main symptoms of abdominal pain .
