CAJ | 학술논문

目的：研究瑞格列奈联合二甲双胍治疗2型糖尿病的临床效果。方法选择2型糖尿病患者作为研究对象，分为瑞格列奈联合二甲双胍治疗的观察组和二甲双胍治疗的对照组，观察两组患者血糖水平、心功能以及下肢神经、运动功能。结果观察组舒张早期充盈峰速度（E峰）、E峰/舒张晚期充盈峰速度（A峰）值、射血分数（LVEF）、左心室舒张末期直径（LVEDD）以及行走距离、行走速度、运动神经的传导速度（MCV）、感觉神经的传导速度（SCV）均明显高于对照组；A峰值、下肢运动神经的潜伏期（LAT）均明显低于对照组；E峰、E峰/A峰、LVEF、LVEDD以及行走距离、行走速度、MCV、SCV均与糖化血红蛋白水平呈负相关，A峰值、LAT均与糖化血红蛋白水平呈正相关。结论瑞格列奈联合二甲双胍能够控制2型糖尿病患者血糖水平，进而起到改善心功能和下肢运动、神经功能的作用，具有积极的临床作用。
목적：연구서격렬내연합이갑쌍고치료2형당뇨병적림상효과。방법선택2형당뇨병환자작위연구대상，분위서격렬내연합이갑쌍고치료적관찰조화이갑쌍고치료적대조조，관찰량조환자혈당수평、심공능이급하지신경、운동공능。결과관찰조서장조기충영봉속도（E봉）、E봉/서장만기충영봉속도（A봉）치、사혈분수（LVEF）、좌심실서장말기직경（LVEDD）이급행주거리、행주속도、운동신경적전도속도（MCV）、감각신경적전도속도（SCV）균명현고우대조조；A봉치、하지운동신경적잠복기（LAT）균명현저우대조조；E봉、E봉/A봉、LVEF、LVEDD이급행주거리、행주속도、MCV、SCV균여당화혈홍단백수평정부상관，A봉치、LAT균여당화혈홍단백수평정정상관。결론서격렬내연합이갑쌍고능구공제2형당뇨병환자혈당수평，진이기도개선심공능화하지운동、신경공능적작용，구유적겁적림상작용。
Objective To study clinical effect of repaglinide combined with metformin in the treatment of type 2 diabetes .Methods A total of 400 patients with type 2 diabetic were divided into observation group ,treated with repaglinide combined with metformin ,and control group ,treated with metformin .Levels of blood sugar ,cardiac func-tion ,and lower limb nerve and motor function were observed .Results Early diastolic peak velocity (E peak) ,ratio of E and late diastolic peak velocity (A peak ,E/A) ,left ventricular ejection fraction (LVEF) ,left ventricular end dias-tolic diameter (LVEDD) ,walking distance ,walking speed ,motor nerve conduction velocity (MCV ) ,sensory nerves conduction velocity (SCV) were significantly higher than control group ,but A peak ,lower extremity motor nerve la-tency (LAT) were significantly lower .E peak ,E/A value ,LVEF ,LVEDD ,walking distance ,walking speed ,MCV and SCV were negatively correlated with glycosylated hemoglobin content ,and A peak and LAT were positively cor-related with glycosylated hemoglobin level .Conclusion Repaglinide combined with metformin could be efficient for controlling blood glucose level in patients with type 2 diabetic ,which could also improve cardiac function ,and lower limb nerve and motor function .