CAJ | 학술논문

目的：观察活性维生素D联合ARB对早期糖尿病肾病微量白蛋白尿的疗效。方法：选取2011-2013年在本院就诊的45例符合早期糖尿病肾病诊断标准的患者，按照随机数字表法将其分为ARB治疗组（A组）、活性维生素D治疗组（B组）、ARB联合活性维生素D治疗组（C组）各15例，各组患者均给予常规糖尿病治疗。疗程16周，观察比较各组治疗前后尿微量白蛋白（U-mAlb）、血TGF-β1指标的变化。结果：治疗16周后，各组尿微量白蛋白、血TGF-β1水平均明显低于治疗前，差异均有统计学意义（P<0.05），其中联合治疗组尿微量白蛋白、血TGF-β1水平下降最明显（P<0.05）。结论：活性维生素D可以减少早期糖尿病肾病尿微量白蛋白，减轻肾脏纤维化，且联合ARB治疗后疗效更为显著，值得临床推广。
목적：관찰활성유생소D연합ARB대조기당뇨병신병미량백단백뇨적료효。방법：선취2011-2013년재본원취진적45례부합조기당뇨병신병진단표준적환자，안조수궤수자표법장기분위ARB치료조（A조）、활성유생소D치료조（B조）、ARB연합활성유생소D치료조（C조）각15례，각조환자균급여상규당뇨병치료。료정16주，관찰비교각조치료전후뇨미량백단백（U-mAlb）、혈TGF-β1지표적변화。결과：치료16주후，각조뇨미량백단백、혈TGF-β1수평균명현저우치료전，차이균유통계학의의（P<0.05），기중연합치료조뇨미량백단백、혈TGF-β1수평하강최명현（P<0.05）。결론：활성유생소D가이감소조기당뇨병신병뇨미량백단백，감경신장섬유화，차연합ARB치료후료효경위현저，치득림상추엄。
To observe the efficacy of active vitamin D combined ARB on microalbuminuria in early diabetic nephropathy.Method:45 patients in accordance with the standard for early diagnosis of diabetic nephropathy in our hospital from 2011 to 2013 were selected,they were randomly divided into the ARB treatment group(the group A), active vitamin D treatment group(the group B),ARB combined active vitamin D treatment group(the group C),15 cases in each group.All patients were given conventional diabetes treatment for 16 weeks.The changes of urine albumin (U-mAlb),serum TGF-β1 before and after treatment in each group were observed and compared.Result:After 16 weeks,urinary albumin and serum TGF-β1 levels of three groups were significantly lower than before treatment,the differences were statistically significant(P<0.05),the urinary albumin and serum levels of TGF-β1 in the combined treatment group decreased significantly(P<0.05).Conclusion:The active vitamin D can reduce microalbuminuria in early diabetic nephropathy and kidney fibrosis,the therapy is more significant when combined with ARB,is worthy of clinical promotion.