CAJ | 학술논문

目的观察贝那普利联合卡维地洛治疗原发性高血压患者的疗效及对心肌肥厚的影响。方法将90例原发性高血压患者随机分为观察组和对照组,观察组用贝那普利加卡维地洛；对照组单用贝那普利。两组疗程均为12月。治疗期间监测血压、空腹血糖、血脂、血钾、血尿酸、尿素氮和肌酐等,观察药物的安全性。结果观察组50例，有效率92%(46/50),血浆血管紧张素Ⅱ(AngⅡ)和醛固酮(Ald)水平明显下降(<0.01)。22例伴有心肌肥厚患者，室间隔厚度( IVST)及左室后壁厚度(LVPWT)、左室舒张末期内径(LVEDd)、左室重量指数(LVMI)明显下降(<0.05)；对照组40例,有效率77.5%(31/40),显著低于观察组(<0.05),对照组AngⅡ和Ald水平有所下降(<0.05)，16例心肌肥厚的患者,超声心动图指标有下降趋势，但无统计学差异(>0.05)；两组治疗前后空腹血糖、血脂、肾功能及电解质无显著变化(>0.05)。结论贝那普利联合卡维地洛治疗原发性高血压患者可安全有效降压,逆转心肌肥厚；改善左室功能。且耐受性好,副作用少,而且对代谢无明显的影响，值得在临床上推广应用。
목적관찰패나보리연합잡유지락치료원발성고혈압환자적료효급대심기비후적영향。방법장90례원발성고혈압환자수궤분위관찰조화대조조,관찰조용패나보리가잡유지락；대조조단용패나보리。량조료정균위12월。치료기간감측혈압、공복혈당、혈지、혈갑、혈뇨산、뇨소담화기항등,관찰약물적안전성。결과관찰조50례，유효솔92%(46/50),혈장혈관긴장소Ⅱ(AngⅡ)화철고동(Ald)수평명현하강(<0.01)。22례반유심기비후환자，실간격후도( IVST)급좌실후벽후도(LVPWT)、좌실서장말기내경(LVEDd)、좌실중량지수(LVMI)명현하강(<0.05)；대조조40례,유효솔77.5%(31/40),현저저우관찰조(<0.05),대조조AngⅡ화Ald수평유소하강(<0.05)，16례심기비후적환자,초성심동도지표유하강추세，단무통계학차이(>0.05)；량조치료전후공복혈당、혈지、신공능급전해질무현저변화(>0.05)。결론패나보리연합잡유지락치료원발성고혈압환자가안전유효강압,역전심기비후；개선좌실공능。차내수성호,부작용소,이차대대사무명현적영향，치득재림상상추엄응용。
Objective To approach the curative ef ect of combine reatment of benazepril and carvedilol and its impact on myocardial hypertrophy in patients with essential hypertension.Methods Ninety hypertensive patients were randomly designed to observation group and control group, the observation group (n=50),which were treated with benazepril and carvedilol, and the control group (n=40), which received treatment with only benazepril. the treating course was 12 months for both groups, Blood pressure、blood glucose、blood fat、serum potassium、blood uricacid、urea nitrogen and creatinine and the safety of drugs were examined. Results After treatment the response rate was 92% in the observation group(n=50), the Serum concentrations of Angl and Ald were significantly decreased ( <0.01);Interventricular septal thickness (IVST) and left ventricular posterior wal thickness (LVPWT), Left ventricular end diastolic diameter (LVEDd),left ventricular mass index (LVMI) were decreased significantly ( <0.05) in 26 patients with cardiac hypertrophy ( <0.05) ;the response rate was 77.5% in the control group, group (n=40), the response rate was significantly lower than that of the observation group, the Serum concentrations of Angl and Ald were sensibly decined( <0.05);The incidence of Doppler echocardiography become lower in 16 atients with cardiac hypertrophy ( < 0.05),but the dif erence was not significant in Statistics ( >0.05 );Fasting blood-glucose, blood fat, renal function and electrolytes had no significant change before and after treatment in dif erent groups.Conclusion Benazepril combined with carvedilol is capable of Safe and ef ective antihypertension,reversing left ventricular hypertrophy and improving cardiac function, it had wel tolerance,lower adverse reactions and no perceptible ef ect on metabolism ,wich should be widely spreaded in clinics should be widely spreaded in clinics.