CAJ | 학술논문

探讨γ干扰素(IFN-γ)基因多态性与弥漫性毒性甲状腺肿(Graves disease，GD)发病易感性的关系。方法：选择汉族GD患者和正常人各100例，采用序列特异性引物聚合酶链反应检测等位基因和基因型。结果：G D组I F N-γ基因+874位点A等位基因的频率明显高于正常对照组(83.5%对70.5%， P<0.05)；GD组IFN-γ+874 AA基因型频率显著高于对照组(72%对51%，P<0.05)。结论：在中国汉族人群中，GD患者和正常人之间存在IFN-γ基因+874位点A等位基因分布的差异。IFN-γ基因+874位点单核苷酸多态性可能是GD的易感因素。
탐토γ간우소(IFN-γ)기인다태성여미만성독성갑상선종(Graves disease，GD)발병역감성적관계。방법：선택한족GD환자화정상인각100례，채용서렬특이성인물취합매련반응검측등위기인화기인형。결과：G D조I F N-γ기인+874위점A등위기인적빈솔명현고우정상대조조(83.5%대70.5%， P<0.05)；GD조IFN-γ+874 AA기인형빈솔현저고우대조조(72%대51%，P<0.05)。결론：재중국한족인군중，GD환자화정상인지간존재IFN-γ기인+874위점A등위기인분포적차이。IFN-γ기인+874위점단핵감산다태성가능시GD적역감인소。
To explore the relationship between the single nucleotide polymorphism of interferon gamma gene +874 site and Graves disease(GD) Methods One hundred Chinese patients with GD and one hundred racial y matched healthy controls were studied. Al eles and genotypes were determined by polymerase chain reaction and sequence specific primers. Results:The frequency of the variant A in the interferon gamma gene +874 site in GD group was significantly higher than that in control group(72% vs 51%;p<0.05). Conclusion: In Chinese population , there were differences between GD patients and controls for frequencies of A al ele in interferon gamma gene +874 site, interferon gamma gene +874 site single nucleotide polymorphism may contribute to increasing the susceptibility to GD.