CAJ | 학술논문

目的：探讨氯吡格雷抵抗对急性冠脉综合征患者经皮冠状动脉介入治疗(PCI)术后临床预后的影响。方法：入选166例急性冠脉综合征行PCI术的患者，检测服用氯吡格雷前后的血小板功能。服用氯吡格雷后血小板聚集率较基线下降≤1O%定义为氯吡格雷抵抗，根据检测结果分为抵抗组和非抵抗组，随访两组12个月的心血管事件(死亡、再次血运重建、非致死性心肌梗死、支架内血栓形成)及再次住院率。结果：两组临床特征及支架植入情况比较，差异无统计学意义(P>0.05)。抵抗组主要心血管不良事件发生率显著高于非抵抗组，抵抗组再次住院率也显著高于非抵抗组(P<0.05)。结论：急性冠脉综合征患者PCI术后存在氯吡格雷抵抗心血管不良事件发生率明显升高。
목적：탐토록필격뢰저항대급성관맥종합정환자경피관상동맥개입치료(PCI)술후림상예후적영향。방법：입선166례급성관맥종합정행PCI술적환자，검측복용록필격뢰전후적혈소판공능。복용록필격뢰후혈소판취집솔교기선하강≤1O%정의위록필격뢰저항，근거검측결과분위저항조화비저항조，수방량조12개월적심혈관사건(사망、재차혈운중건、비치사성심기경사、지가내혈전형성)급재차주원솔。결과：량조림상특정급지가식입정황비교，차이무통계학의의(P>0.05)。저항조주요심혈관불량사건발생솔현저고우비저항조，저항조재차주원솔야현저고우비저항조(P<0.05)。결론：급성관맥종합정환자PCI술후존재록필격뢰저항심혈관불량사건발생솔명현승고。
Objective:To investigate the correlation between clopidogrel resistance and long-term prognosis of acute coronary syndrome(ACS) patients implanted with drug-duting stents.Method:166 patients that undergone percutaneous coronary interventional(PCI) were enrolled.Platelet aggregation at baseline and 24 hours after clopidogrel treatment was examined.Clopidogrel resistance was defined as a decrease in platelet aggregation≤10%in response to ADP.Patients were divided into clopidogrel resistance group and clopidogrel no-resistance group. The twelve-month clinical endpoint(death,myocardial infarction,coronary revascularization and stent thrombosis)and rehospitalztion rate were compared.Result:During 12 months follow-up,the incidence of major adverse cardiovascular events was significantly higher in resistance group than that in no-resistance group(P<0.05).Hospitalization for cardiovascular events was also significantly higher in resistance meanwhile(P<0.05).Conclusion:Clopidogrel resistance may contribute to long-term prognosis of acute coronary syndrome patients implanted with drug-duting stents.