医药前沿
醫藥前沿
의약전연
YIAYAO QIANYAN
2014年
19期
138-139
,共2页
吴军%陈家香%陈兰%王正凤%李贵香%余春梅
吳軍%陳傢香%陳蘭%王正鳳%李貴香%餘春梅
오군%진가향%진란%왕정봉%리귀향%여춘매
罗红霉素片%正交设计%处方工艺
囉紅黴素片%正交設計%處方工藝
라홍매소편%정교설계%처방공예
Roxithromycin capsules%Orthogonal design%Formula technology
制备罗红霉素片，筛选出最佳处方工艺。方法：采用正交设计法，以溶出度作为考察指标，进行处方筛选、优化。结果：最佳处方中预胶化淀粉(A)，低取代羟丙纤维素(B)，泊洛沙姆(C)分别为80mg，40mg，3mg，3批优化处方的样品，以及市售样品在标准介质中15分钟溶出度均大于85%。结论：罗红霉素片优化处方合理，工艺简单，溶出行为与被仿样品具有一致性。
製備囉紅黴素片，篩選齣最佳處方工藝。方法：採用正交設計法，以溶齣度作為攷察指標，進行處方篩選、優化。結果：最佳處方中預膠化澱粉(A)，低取代羥丙纖維素(B)，泊洛沙姆(C)分彆為80mg，40mg，3mg，3批優化處方的樣品，以及市售樣品在標準介質中15分鐘溶齣度均大于85%。結論：囉紅黴素片優化處方閤理，工藝簡單，溶齣行為與被倣樣品具有一緻性。
제비라홍매소편，사선출최가처방공예。방법：채용정교설계법，이용출도작위고찰지표，진행처방사선、우화。결과：최가처방중예효화정분(A)，저취대간병섬유소(B)，박락사모(C)분별위80mg，40mg，3mg，3비우화처방적양품，이급시수양품재표준개질중15분종용출도균대우85%。결론：라홍매소편우화처방합리，공예간단，용출행위여피방양품구유일치성。
To prepare Roxithromycin capsules,and to optimize the best formula technology.Methods:The formula was optimized by orthogonal design using dissolution as index.Results:The optimal formula of Roxithromycin capsules was as fol owed:amylum pregelatinisatum (A),L-hydroxypropylcel ulose (B),poloxamer (C) were 80mg,40mg,3mg, respectively.The dissolution of 3 batches of our samples and control article was more than 85%,.Conclusion: The formula of Roxithromycin capsules is reasonable, technology is simple, essential y,the dissolution curve in vitro was similar to imitation.
