CAJ | 학술논문

探讨脓毒症患儿并发脓毒症相关性脑病（sepsis associated encephalopathy,SAE）的危险因素。方法收集珠海市妇幼保健院104例脓毒症患儿的临床资料，采用单因素分析和多因素Logisitic回归分析儿童脓毒症相关性脑病发生的危险因素。结果合并脑病的脓毒症患儿病死率显著高于无合并脑病的脓毒症患儿；有凝血功能障碍患SAE的比例高于没有凝血功能障碍的患儿；小儿危重病例评分（PCIS评分）≤80分的患SAE比例高于＞80分组；尿素氮(BUN)、皮肤毛细血管再充盈时间（CRT）在SAE组与无SAE组的之间的差异有统计学意义（P<0.05），SAE组显著高于无SAE组。结论凝血功能障碍及PCIS≤80分对脓毒症相关性脑病的发生有影响作用。
탐토농독증환인병발농독증상관성뇌병（sepsis associated encephalopathy,SAE）적위험인소。방법수집주해시부유보건원104례농독증환인적림상자료，채용단인소분석화다인소Logisitic회귀분석인동농독증상관성뇌병발생적위험인소。결과합병뇌병적농독증환인병사솔현저고우무합병뇌병적농독증환인；유응혈공능장애환SAE적비례고우몰유응혈공능장애적환인；소인위중병례평분（PCIS평분）≤80분적환SAE비례고우＞80분조；뇨소담(BUN)、피부모세혈관재충영시간（CRT）재SAE조여무SAE조적지간적차이유통계학의의（P<0.05），SAE조현저고우무SAE조。결론응혈공능장애급PCIS≤80분대농독증상관성뇌병적발생유영향작용。
Objective Investigating on the risk factors of sepsis sepsis associated encephalopathy in children.Methods Collecting the clinical data of 104 cases of children with sepsis, adopting single factor analysis and multi-factor logistic regression analysis to study on the risk factors influencing the occurrence of sepsis associated encephalopathy in children.Results The mortality rate of children with sepsis associated encephalopathy was obviously higher than children with sepsis but no encephalopathy; the proportion of children suffering from sepsis associated encephalopathy with coagulation disorders was higher than children with no coagulation disorders; the proportion of children suffering SAE in cases whose Pediatric Clinical Illness Score (PCIS grade)≤80 grade was highter than thatof above 80 grade group; The difference of urea nitrogen (BUN) and capillary refill time (CRT) in SAE group and no SAE group had statistical significance, and the BUN and CRT in group with sepsis associated encephalopathy was obviously higher than that with no sepsis associated encephalopathy.Conclusion Coagulation disorders and PCIS≤80 grade may be the risk factors to occurrence of sepsis associated encephalopathy.