CAJ | 학술논문

目的：测定小于胎龄儿体内生长素、胰岛素样生长因子-1、瘦素水平，并分析其在生长追赶现象中的作用。方法将156例新生儿分为适于胎龄儿组与小于胎龄儿组，小于胎龄儿组根据有无生长追赶现象的出现又分为有追赶现象组和无追赶现象组。比较其发育指标及生长调节因子水平。结果小于胎龄儿组的发育指标、瘦素、胰岛素样生长因子-1均小于适于胎龄组，生长素水平显著高于适于胎龄组。适于胎龄组的体质量标准得分、身高标准得分、胰岛素样生长因子-1、瘦素水平均高于有追赶现象组与无追赶现象组，生长素水平低于有追赶现象组与无追赶现象组。生长素与体质量标准得分呈负相关，与身高标准得分无相关性；胰岛素样生长因子-1、瘦素水平与体质量标准得分、身高标准得分均呈正相关。结论小于胎龄儿在出生后存在生长素高水平，瘦素、胰岛素样生长因子-1低水平的状态，3种因子在胎儿生长发育中起着重要的调节作用。
목적：측정소우태령인체내생장소、이도소양생장인자-1、수소수평，병분석기재생장추간현상중적작용。방법장156례신생인분위괄우태령인조여소우태령인조，소우태령인조근거유무생장추간현상적출현우분위유추간현상조화무추간현상조。비교기발육지표급생장조절인자수평。결과소우태령인조적발육지표、수소、이도소양생장인자-1균소우괄우태령조，생장소수평현저고우괄우태령조。괄우태령조적체질량표준득분、신고표준득분、이도소양생장인자-1、수소수평균고우유추간현상조여무추간현상조，생장소수평저우유추간현상조여무추간현상조。생장소여체질량표준득분정부상관，여신고표준득분무상관성；이도소양생장인자-1、수소수평여체질량표준득분、신고표준득분균정정상관。결론소우태령인재출생후존재생장소고수평，수소、이도소양생장인자-1저수평적상태，3충인자재태인생장발육중기착중요적조절작용。
Objective To determine Ghrelin,IGF-1 and leptin levels and analyze the role of catch-up growth phe-nomenon. Methods 156 cases of fetus arranged in small for gestational age group(SGA group)and appropriate for gestional-age group(AGA group). The SGA group was divided into CUG group and non CUG group according to the presence or absence of catch-up growth phenomenon. The growth index and growth regulating factor were compared. Results The growth index (Height,weight,head circumference),IGF-1 and leptin levels of SGA group were lower than AGA group,but Ghrelin were higher than AGA group. The Body quality standard score,height standard score,IGF-1 and leptin of AGA group were higher than CUG group and non CUG group,but the Ghrelin were lower than CUG group and non CUG group. Ghrelin was negatively related to wtSDS,and no significant correlation with HtSDS. IGF-1 and leptin were negatively related to wtSDS and HtSDS. Conclusion SGA has higher levels of Ghrelin after birth,but lower level of IGF-1 and leptin. There three factors in fetal growth play an important role in process of growth and development of fetus.