CAJ | 학술논문

目的：观察四联疗法联用微生态制剂枯草杆菌二联活菌肠溶胶囊根除幽门螺杆菌（ Hp）治疗中 Hp根除率及不良反应的影响。方法将300例 Hp 阳性的十二指肠溃疡及慢性胃炎伴糜烂患者随机分为观察组与对照组各150例。对照组予常规四联疗法治疗，观察组在对照组基础上加用枯草杆菌二联活菌肠溶胶囊。服药第3、10天分别调查患者的不良反应发生率；治疗结束4周后复查14 C-尿素呼气试验，了解 Hp 根除率。结果对照组与观察组Hp 根除率分别为92.0%和93.3%，2组比较差异无统计学意义（P ﹥0.05）。观察组胃肠道不良反应发生率明显低于对照组，差异有统计学意义（P ﹤0.01）。结论传统四联疗法联用微生态制剂枯草杆菌二联活菌肠溶胶囊治疗 Hp 疗效显著，不良反应发生率较单用四联疗法显著降低，效果肯定，值得临床推广应用。
목적：관찰사련요법련용미생태제제고초간균이련활균장용효낭근제유문라간균（ Hp）치료중 Hp근제솔급불량반응적영향。방법장300례 Hp 양성적십이지장궤양급만성위염반미란환자수궤분위관찰조여대조조각150례。대조조여상규사련요법치료，관찰조재대조조기출상가용고초간균이련활균장용효낭。복약제3、10천분별조사환자적불량반응발생솔；치료결속4주후복사14 C-뇨소호기시험，료해 Hp 근제솔。결과대조조여관찰조Hp 근제솔분별위92.0%화93.3%，2조비교차이무통계학의의（P ﹥0.05）。관찰조위장도불량반응발생솔명현저우대조조，차이유통계학의의（P ﹤0.01）。결론전통사련요법련용미생태제제고초간균이련활균장용효낭치료 Hp 료효현저，불량반응발생솔교단용사련요법현저강저，효과긍정，치득림상추엄응용。
Objective To observe the eradication rate and side-effect about quadruple therapy combined medilac-S to eradicate helicobacter-pylori. Methods 300 cases of patients with peptic ulcer or chronic gastritis were divided into observa-tion group and control group randomly,each of 150 cases. The control group was only treated by routine quadruple therapy, while the observation group was treated by quadruple therapy and medilac-S. The side-effects questionnaire was investigated on the third and tenth day. After 4 weeks,the Hp eradicate rate were compared by doing the 14 C urea breath test. Results The Hp eradication rate of the observation group and the control group were 92% and 93. 3% respectively,the difference was not statistically significant(P ﹥ 0. 05). The gastrointestinal side-effects were obviously fewer in observation group than that in con-trol group ,the difference was statistically significant(P ﹤ 0. 01). Conclution The effect of medilac-S combined with quad-ruple therapy is remarkable in the treatment of helicobacter - pylori ,with fewer side-effects,which is worthy of clinical applica-tion.