中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2014年
26期
2008-2012
,共5页
刘小兵%倪启超%盛陈毅%马菁%王庆庆
劉小兵%倪啟超%盛陳毅%馬菁%王慶慶
류소병%예계초%성진의%마정%왕경경
乳腺肿瘤%Emi1%基因表达调控,肿瘤%预后
乳腺腫瘤%Emi1%基因錶達調控,腫瘤%預後
유선종류%Emi1%기인표체조공,종류%예후
Breast neoplasms%Emi1%Gene expression regulation,Neoplasms%Prognosis
目的:通过检测新发现的癌基因Emi1在乳腺癌中的表达情况,探讨其与乳腺癌癌变的关系及其预后意义。方法收集93例乳腺癌及癌旁组织,采用免疫组织化学法检测Emi1在这些组织中的表达,并与增殖细胞核抗原(Ki-67)的表达相比较。结合临床病理资料分析该分子在乳腺癌中的临床意义。结果 Emi1在乳腺癌组织中高表达,且Emi1的表达与乳腺癌的组织分化程度( P=0.002),淋巴结转移(P=0.017)及ER(P=0.038)有关,但与患者的年龄、肿瘤大小、组织学类型、孕激素受体(PR)、人表皮生长因子受体2(HER-2)、P53等临床病理参数无关。而乳腺癌中Ki-67的表达与Emi1表达变化结果相似。相关性分析表明乳腺癌组织中Emi1的表达与Ki-67的表达呈明显正相关( r2=0.454,P=0.002)。多因素分析发现:组织分化程度、淋巴结状态、Ki-67和Emi1的表达与患者的总生存率均有明显的相关性。结论 Emi1是一个新的乳腺癌相关基因,很可能在乳腺癌的浸润转移中起重要作用,是乳腺癌患者的一个重要预后指标,可作为潜在的治疗靶点。
目的:通過檢測新髮現的癌基因Emi1在乳腺癌中的錶達情況,探討其與乳腺癌癌變的關繫及其預後意義。方法收集93例乳腺癌及癌徬組織,採用免疫組織化學法檢測Emi1在這些組織中的錶達,併與增殖細胞覈抗原(Ki-67)的錶達相比較。結閤臨床病理資料分析該分子在乳腺癌中的臨床意義。結果 Emi1在乳腺癌組織中高錶達,且Emi1的錶達與乳腺癌的組織分化程度( P=0.002),淋巴結轉移(P=0.017)及ER(P=0.038)有關,但與患者的年齡、腫瘤大小、組織學類型、孕激素受體(PR)、人錶皮生長因子受體2(HER-2)、P53等臨床病理參數無關。而乳腺癌中Ki-67的錶達與Emi1錶達變化結果相似。相關性分析錶明乳腺癌組織中Emi1的錶達與Ki-67的錶達呈明顯正相關( r2=0.454,P=0.002)。多因素分析髮現:組織分化程度、淋巴結狀態、Ki-67和Emi1的錶達與患者的總生存率均有明顯的相關性。結論 Emi1是一箇新的乳腺癌相關基因,很可能在乳腺癌的浸潤轉移中起重要作用,是乳腺癌患者的一箇重要預後指標,可作為潛在的治療靶點。
목적:통과검측신발현적암기인Emi1재유선암중적표체정황,탐토기여유선암암변적관계급기예후의의。방법수집93례유선암급암방조직,채용면역조직화학법검측Emi1재저사조직중적표체,병여증식세포핵항원(Ki-67)적표체상비교。결합림상병리자료분석해분자재유선암중적림상의의。결과 Emi1재유선암조직중고표체,차Emi1적표체여유선암적조직분화정도( P=0.002),림파결전이(P=0.017)급ER(P=0.038)유관,단여환자적년령、종류대소、조직학류형、잉격소수체(PR)、인표피생장인자수체2(HER-2)、P53등림상병리삼수무관。이유선암중Ki-67적표체여Emi1표체변화결과상사。상관성분석표명유선암조직중Emi1적표체여Ki-67적표체정명현정상관( r2=0.454,P=0.002)。다인소분석발현:조직분화정도、림파결상태、Ki-67화Emi1적표체여환자적총생존솔균유명현적상관성。결론 Emi1시일개신적유선암상관기인,흔가능재유선암적침윤전이중기중요작용,시유선암환자적일개중요예후지표,가작위잠재적치료파점。
Objective To examine the expression and prognostic value of novel oncogene Emi 1 in breast cancer.Methods Immunohistochemical analysis was performed for 93 human breast carcinoma samples and adjacent normal tissues for detecting the expression of Emi 1 and cell proliferative factor Ki-67.Then the data were correlated with clinicopathological features.Results Emi1 was highly expressed in breast carcinoma tissues compared with adjacent normal tissues.Emi1 expression was significantly associated with histological grade ( P=0.002 ) , axillary lymph node status ( P =0.017 ) and ER status ( P =0.038 ).However , there was no correlation between Emi 1 expression and other factors such as age , tumor size , histology, PR status, HER-2 or P53.Meanwhile similar results were obtained for Ki-67 expression.A marked correlation also existed between Emi 1 and Ki-67 expression (Spearman′s r2 =0.454, P=0.002). Conclusion As a novel breast cancer associated gene , Emil plays an important role in evaluating invasion and metastatic potentiality in breast cancer.And it is also an important prognostic predictor of breast cancer so as to become a potential therapeutic target for breast cancer.