CAJ | 학술논문

目的：研究心脑宁片对地塞米松磷酸钠注射液致大鼠血瘀模型症状积分、血液K值、变性指数、电泳指数的影响。方法取大鼠60只，随机均匀分为6组，其中1组为空白对照组，其余5组为大鼠造血瘀模型，分别为模型组、脑安片组、大、中、小剂量心脑宁片组。评价大鼠血瘀症状积分，测血液K值、变性指数、电泳指数。结果造模成功，模型组和各给药组均出现显著血液症状（P＜0．01）；以大剂量心脑宁片组对血瘀症状的改善作用为好。大、中剂量心脑宁片组和脑安片组可显著降低K值（P＜0．01）；心脑宁片组可使变性指数显著变大（P＜0．01）；心脑宁片组可使电泳指数显著变大（P＜0．01）。结论心脑宁片有很好的改善血瘀的作用。
목적：연구심뇌저편대지새미송린산납주사액치대서혈어모형증상적분、혈액K치、변성지수、전영지수적영향。방법취대서60지，수궤균균분위6조，기중1조위공백대조조，기여5조위대서조혈어모형，분별위모형조、뇌안편조、대、중、소제량심뇌저편조。평개대서혈어증상적분，측혈액K치、변성지수、전영지수。결과조모성공，모형조화각급약조균출현현저혈액증상（P＜0．01）；이대제량심뇌저편조대혈어증상적개선작용위호。대、중제량심뇌저편조화뇌안편조가현저강저K치（P＜0．01）；심뇌저편조가사변성지수현저변대（P＜0．01）；심뇌저편조가사전영지수현저변대（P＜0．01）。결론심뇌저편유흔호적개선혈어적작용。
Objective To study the effect of Xinnaoning tablets on blood stasis rat model which was caused to dexamethasone sodium phosphate injection with symptom score , K-value of blood, modified index, electrophoresis index.Methods 60 rats, were di-vided into 6 groups stochastically , and 1 group for vacuity contrast group , the other 5 groups for blood stasis model , the 5 groups were model group , Naoan tablets group , high dose , medium dose and low dose Xinnaoning tablets groups .Symptom score were evaluated , K-value of blood , Modified index , Electrophoresis index were measured .Results The Model was constructed successfully , model group and administrate groups had significant blood symptoms (P<0.01).The effect of high dose Xinnaoning tablets group to blood stasis rat model which was caused to dexamethasone sodium phosphate injection was best .High dose and medium dose Xinnaoning tab-lets groups could induce K-value significantly (P<0.01).Xinnaoning tablets groups could improve modified index and electrophore-sis index significantly (P<0.01), and the effect of high dose and medium dose Xinnaoning tablets groups to blood stasis rat model which was caused to dexamethasone sodium phosphate injection were better .Conclusion Xinnaoning tablets had good improvement effect on blood stasis .