CAJ | 학술논문

目的：采用近红外漫反射光谱分析技术和模式识别技术建立消旋山莨菪碱非铝塑包装片剂定性分析模型用于该品种的鉴别。方法以8个生产厂家的消旋山莨菪碱为分析对象，采集近红外漫反射光谱，通过导数化和矢量归一化进行预处理，应用欧氏距离方法建立消旋山莨菪碱近红外鉴别数学模型。结果消旋山莨菪碱的定性分析模型的条件参数为：谱段为5400～7000 cm-1，光谱预处理方法为“一阶导数法＋归一化”，模型的阈值为0．603。并对模型进行了验证，能满足应用的要求。结论试验结果表明应用近红外光谱技术建立消旋山莨菪碱的定性分析模型是可行的，同时为模型更新提供了一个参考的方法。
목적：채용근홍외만반사광보분석기술화모식식별기술건립소선산랑탕감비려소포장편제정성분석모형용우해품충적감별。방법이8개생산엄가적소선산랑탕감위분석대상，채집근홍외만반사광보，통과도수화화시량귀일화진행예처리，응용구씨거리방법건립소선산랑탕감근홍외감별수학모형。결과소선산랑탕감적정성분석모형적조건삼수위：보단위5400～7000 cm-1，광보예처리방법위“일계도수법＋귀일화”，모형적역치위0．603。병대모형진행료험증，능만족응용적요구。결론시험결과표명응용근홍외광보기술건립소선산랑탕감적정성분석모형시가행적，동시위모형경신제공료일개삼고적방법。
Objective To develop an identification model of raceanisodamine tablets by diffuse reflection near -infrared spec-troscopy and pattern recognition .Methods The diffuse reflectance spectra in the 12 000-4 000 cm-1 spectral coverage range of racean-isodamine tablets from eight different pharmaceutical factories were collected to establish the identification model .A mono-component near infrared model was established for raceanisodamine tablets .Results The parameters of the identification model for the raceaniso-damine tablets was as follows:spectral range was 5 400-7 000 cm-1 ,the pretreatment method was first derivative and normalization;the threshold was 0.603.And the model was validated , which met the requirements of application .Conclusion The results showed that identification model for the raceanisodamine tablets by near infrared spectroscopy was feasible , which provided a reference method for the model updating .