CAJ | 학술논문

肿瘤严重威胁人类生命健康，因此发现新结构类型、新作用机制、更有效的抗肿瘤药成为当务之急。天然产物在抗肿瘤药物发现过程中有着重要的作用和意义。综述几种具有抗肿瘤活性的天然产物，重点阐述其作用机制、抗肿瘤活性及构效关系的研究进展。
종류엄중위협인류생명건강，인차발현신결구류형、신작용궤제、경유효적항종류약성위당무지급。천연산물재항종류약물발현과정중유착중요적작용화의의。종술궤충구유항종류활성적천연산물，중점천술기작용궤제、항종류활성급구효관계적연구진전。
Cancer is a serious threat to human life and health .Therefore, there is an emergent need to develop novel anti-cancer agents with new structural type , new mechanism of action and higher efficacy .Natural products had played a key role in the dis-covery of anticancer agents .The anti-cancer activity , mechanism of action , structure and activity relationship of several lead-com-pounds which were derived from natural products were summarized in this review .