CAJ | 학술논문

基因嵌合现象普遍存在于各种癌症中，嵌合基因（chimeric gene）和蛋白在肿瘤发生中发挥重要作用。嵌合基因在人类多种疾病，特别是癌症中过度表达，但分子机制并不明确。近年来，有关嵌合基因的分子机制逐渐清晰，人们对发病较高的前列腺癌、肺癌以及白血病中过度表达的嵌合基因进行深入探索，也为未来肿瘤的诊断和治疗提供非常重要的理论依据。
기인감합현상보편존재우각충암증중，감합기인（chimeric gene）화단백재종류발생중발휘중요작용。감합기인재인류다충질병，특별시암증중과도표체，단분자궤제병불명학。근년래，유관감합기인적분자궤제축점청석，인문대발병교고적전렬선암、폐암이급백혈병중과도표체적감합기인진행심입탐색，야위미래종류적진단화치료제공비상중요적이론의거。
The formation of chimeric genes is a common event in a variety of cancers .The chi-meric genes and proteins play significant roles in tumorigenesis .They over-express in a variety of dis-ease, especially in cancers.However, most of the biological functions of chimeric genes remain un -known.Recently, over-expressed chimeric genes have been recognized as biomarkers for cancers .In this review, we highlight some recent advances of chimeric genes in cancer metastasis .