CAJ | 학술논문

随着分子生物学技术的发展，应用DNA重组技术、抗体库技术及转基因技术对鼠源性单抗进行人源化改造，先后出现了嵌合抗体、互补决定区移植抗体和全人源抗体，它们从不同角度克服了鼠源性单抗临床应用的不足，为单克隆抗体在临床诊断及治疗中的应用带来了新的曙光，该文对单克隆抗体人源化技术的研究进展作一综述。
수착분자생물학기술적발전，응용DNA중조기술、항체고기술급전기인기술대서원성단항진행인원화개조，선후출현료감합항체、호보결정구이식항체화전인원항체，타문종불동각도극복료서원성단항림상응용적불족，위단극륭항체재림상진단급치료중적응용대래료신적서광，해문대단극륭항체인원화기술적연구진전작일종술。
With the development of molecular biology, people can humanize mouse monoclonal antibody with DNA recombination, antibody library and transgenic technology which developed antibody techniques from chimeric and grafted antibody to fully human antibody. The humanized monoclonal anti-bodies overcome the clinical shortage of mouse monoclonal antibody from different angles, also bring a new dawn to the diagnosis and treatment of human disease. This article will summarize the progress on the hu-manization of mouse monoclonal antibody.