CAJ | 학술논문

阿尔茨海默病（AD）严重危害人们的身心健康。伴随PET分子成像的发展，出现了一系列针对AD的正电子药物，其中匹兹堡化合物B（PIB）及其衍生物类PET正电子药物研究最为成熟，部分已获准应用于临床，在AD诊断与治疗方面显示出重要价值。随着人们对AD发生机制研究的不断深入，近年又相继出现了包括蛋白类、受体类以及肽类在内的更多种类AD相关PET正电子药物。该文就此类正电子药物的应用与研究进展做一综述。
아이자해묵병（AD）엄중위해인문적신심건강。반수PET분자성상적발전，출현료일계렬침대AD적정전자약물，기중필자보화합물B（PIB）급기연생물류PET정전자약물연구최위성숙，부분이획준응용우림상，재AD진단여치료방면현시출중요개치。수착인문대AD발생궤제연구적불단심입，근년우상계출현료포괄단백류、수체류이급태류재내적경다충류AD상관PET정전자약물。해문취차류정전자약물적응용여연구진전주일종술。
Alzheimer disease(AD) harms human being′s health seriously. With the development progress of PET molecular imaging, a series of PET positron tracers associated with AD appeard. Among them, pittsburgh compound-B(PIB) and PIB derivatives are studied more deeply and part of them have been used in clinic which are showing great value in diagnosis and therapy of AD. Recently, with the deep-er research of AD mechanism , more kinds of PET tracers related to AD are developed, including protein , receptor and peptide radiotracers. This article reviews the current application and research progress of those PET positron tracers which associated with AD.