国际放射医学核医学杂志
國際放射醫學覈醫學雜誌
국제방사의학핵의학잡지
INTERNATIONAL JOURNAL OF RADIATION MEDICINE AND NUCLEAR MEDICINE
2014年
5期
309-314
,共6页
磁共振成像%动态增强%肿瘤%抗血管治疗%药物评价
磁共振成像%動態增彊%腫瘤%抗血管治療%藥物評價
자공진성상%동태증강%종류%항혈관치료%약물평개
Magnetic resonance imaging%Dynamic contrast-enhanced%Tumors%Antivasculra therapy%Drug evaluation
动态增强磁共振成像（DCE-MRI）正逐渐被应用于抗肿瘤血管药物的早期临床试验。该文将对传统临床试验药效评价体系应用于抗肿瘤血管分子靶向药物研发中所存在的问题、DCE-MRI的相应技术原理、DCE-MRI临床应用现状与其在临床试验中的优势、存在的问题与展望做一综述，并列举一些近年来应用DCE-MRI技术进行抗肿瘤血管分子靶向药物临床试验的典型案例。
動態增彊磁共振成像（DCE-MRI）正逐漸被應用于抗腫瘤血管藥物的早期臨床試驗。該文將對傳統臨床試驗藥效評價體繫應用于抗腫瘤血管分子靶嚮藥物研髮中所存在的問題、DCE-MRI的相應技術原理、DCE-MRI臨床應用現狀與其在臨床試驗中的優勢、存在的問題與展望做一綜述，併列舉一些近年來應用DCE-MRI技術進行抗腫瘤血管分子靶嚮藥物臨床試驗的典型案例。
동태증강자공진성상（DCE-MRI）정축점피응용우항종류혈관약물적조기림상시험。해문장대전통림상시험약효평개체계응용우항종류혈관분자파향약물연발중소존재적문제、DCE-MRI적상응기술원리、DCE-MRI림상응용현상여기재림상시험중적우세、존재적문제여전망주일종술，병열거일사근년래응용DCE-MRI기술진행항종류혈관분자파향약물림상시험적전형안례。
The development and research of antivascular medicine has already exerted challenges for traditional clinical trials and its evaluation system. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), as an uninvasive method to visualize and assess vascular structure and function, has been gradually utilized in clinical trials of antivascular medicine and improving stepwise with a view to further detecting angiogenesis of tumor and effects of medicine. This review will articulate on defects of traditional evaluation system in clinical trials of antivascular medicine, technological characteristics of DCE-MRI as well as pros and cons of its application in clinical trials. The detailed utilization of DCE-MRI in some early phase clinical trials during recent years will also be orchestrated in this review.
