CAJ | 학술논문

川崎病在发达国家已经取代风湿热成为儿童最常见的后天性心脏病，但其病因仍然不明。川崎病动物模型可以帮助我们更好地研究川崎病和制定新的有效的治疗方案。在已有的动物模型中，单次腹腔注射干酪乳杆菌细胞壁萃取物诱导小鼠冠状动脉炎模型较为成熟。该文就干酪乳杆菌细胞壁萃取物诱导的小鼠川崎病模型的建立及其相关研究进展作一综述。
천기병재발체국가이경취대풍습열성위인동최상견적후천성심장병，단기병인잉연불명。천기병동물모형가이방조아문경호지연구천기병화제정신적유효적치료방안。재이유적동물모형중，단차복강주사간락유간균세포벽췌취물유도소서관상동맥염모형교위성숙。해문취간락유간균세포벽췌취물유도적소서천기병모형적건립급기상관연구진전작일종술。
Kawasaki disease has replaced rheumatic fever as the most common acquired heart disease in childhood,but its etiology remains unknown. The development and analyses of animal models will help us under-stand KD and find new and effective therapeutic strategies for it. Among these existing animal models, mouse modelof coronary artery inflammation induced by a single intraperitoneal injection of lactobacillus casei cell wall extract is a relatively mature model. In this review,we present an overview of how this model established and some progress in research of the mouse model.