CAJ | 학술논문

身材矮小在儿童内分泌疾病中占较大比例,其病因具有复杂性和交叉性,是儿童生理及心理问题的危险因素之一,需正确诊断并及时治疗。胰岛素样生长因子-1生成试验通过重组人生长激素刺激外周靶细胞分泌胰岛素样生长因子-1,根据胰岛素样生长因子-1的反应情况以评价重组人生长激素的刺激效应,从而进一步诊断身材矮小类型,及时评估重组人生长激素治疗疗效,实现个性化治疗。
신재왜소재인동내분비질병중점교대비례,기병인구유복잡성화교차성,시인동생리급심리문제적위험인소지일,수정학진단병급시치료。이도소양생장인자-1생성시험통과중조인생장격소자격외주파세포분비이도소양생장인자-1,근거이도소양생장인자-1적반응정황이평개중조인생장격소적자격효응,종이진일보진단신재왜소류형,급시평고중조인생장격소치료료효,실현개성화치료。
Short stature accounts for a large proportion of endocrine diseases in children,with a complex and cross-cutting etiology. It is one of the risk factors for physical and psychological problems in children,and needs proper diagnosis and timely treatment. The insulin-like growth factor-1 ( IGF-1 ) generation test is via re-combinant human growth hormone(rhGH)stimulating peripheral target cells to secrete IGF-1. The effects of rh-GH stimulation are then evaluated according to the responsiveness of IGF-1,which is not only helpful for further determination of clinical classification of short stature,but also for therapy assessment of rhGH in time and a-chievement of personalized treatment.