CAJ | 학술논문

目的探讨 CD30在结外鼻型 NK/T 细胞淋巴瘤（NKTCL）中的表达及其意义。方法免疫组织化学检测 CD30在30例 NKTCL 中的表达，同时分析 CD30的表达与 NKTCL 临床病例特征之间的关系。结果NKTCL CD30的表达率为30.0％（9/30）；患者5年总体生存率与 CD30的表达有显著关系（P ＝0.032）；CD30表达与患者的肿瘤分级有关（P ＝0.035）；Cox 回归分析显示，CD30在统计学上可以作为独立预后指标（P ＝0.003）。结论CD30的表达与 NKTCL 患者5年总体生存率有关，而且也许可以作为一个独立的预后指标。
목적탐토 CD30재결외비형 NK/T 세포림파류（NKTCL）중적표체급기의의。방법면역조직화학검측 CD30재30례 NKTCL 중적표체，동시분석 CD30적표체여 NKTCL 림상병례특정지간적관계。결과NKTCL CD30적표체솔위30.0％（9/30）；환자5년총체생존솔여 CD30적표체유현저관계（P ＝0.032）；CD30표체여환자적종류분급유관（P ＝0.035）；Cox 회귀분석현시，CD30재통계학상가이작위독립예후지표（P ＝0.003）。결론CD30적표체여 NKTCL 환자5년총체생존솔유관，이차야허가이작위일개독립적예후지표。
Objective To investigate the pathological and clinical significance of CD30 in extranodal nasal type NK/T cell lymphoma (NKTCL). Methods We detected CD30 expression using immunohistochemistry staining in 30 cases of NK-TCL.Moreover,we analyzed the relationship between CD30 and the clinical pathological features of NKTCL. Results Our re-sults showed that CD30 expression was found in 30.0%(9 /30);CD30 expression was associated with 5-year overall survival rate (P =0.032)as well as tumor stage (P =0.035).Moreover,Cox regression test showed that CD30 expression were statistically independent prognostic factors for NKTCL patients(P =0.003). Conclusion Our results suggested that 5-year overall survival rate of NKTCL patients was associated with CD30 expression which may be considered as an independent prognostic factor.