CAJ | 학술논문

华法林是一种用于预防血栓栓塞性疾病的抗凝药。服用华法林期间对于用量的监测非常重要，凝血酶原时间是外源性凝血途径的筛选性实验，也是口服华法林抗凝治疗监测的首选实验室指标。临床上习惯使用标准化的凝血酶原时间，即国际标准化比值来调整华法林剂量。多种草药与食物可以增强华法林的抗凝效果，而有些草药与食物可以降低华法林的抗凝效果。抗凝过度或者抗凝不足均可引起严重的临床症状。
화법림시일충용우예방혈전전새성질병적항응약。복용화법림기간대우용량적감측비상중요，응혈매원시간시외원성응혈도경적사선성실험，야시구복화법림항응치료감측적수선실험실지표。림상상습관사용표준화적응혈매원시간，즉국제표준화비치래조정화법림제량。다충초약여식물가이증강화법림적항응효과，이유사초약여식물가이강저화법림적항응효과。항응과도혹자항응불족균가인기엄중적림상증상。
Warfarin is a well-accepted drug used for preventing thromboembolic diseases. It is important to monitor the dosage of warfarin. Prothrombin time is one of the screening tests of extrinsic coagulation path,which is the first choice to monitor the oral use of warfarin. Standardized prothrombin time, namely international normalized ratio ( INR ) is used to adjust warfarin dosage in clinical practice. Many herbal medicines and foods may enhance the effect of warfarin therapy,and some of them may weaken this effect,which can result in severe clinical complications.