CAJ | 학술논문

目的：调查我国一般人群血和尿中锰、钴、钼水平，分析其人群分布特点。方法2009至2010年，在我国东部、西部和中部8个省份的24个市县，采用整群随机抽样的方法抽取了18120名6～60岁人群为研究对象，对其生活习惯和健康状况进行了问卷调查，并分别采集其静脉抗凝血样和尿样。用电感耦合等离子体质谱法对血样和尿样进行锰、钴、钼含量检测，通过统计学分析不同年龄、性别人群血和尿中锰、钴、钼水平的分布。结果我国一般人群血锰几何均数为8.98μg/L，男性和女性血锰几何均数分别为8.14、9.88μg/L（Z＝-18.84，P＜0.01）；尿锰几何均数为0.63μg/L，男性和女性尿锰几何均数分别为0.62、0.63μg/L（ Z＝-0.67，P＞0.05）；血钴几何均数为0.194μg/L，男性和女性血钴几何均数分别为0.166、0.225μg/L （ Z ＝-23.04， P ＜0.01）；尿钴几何均数为0.282μg/L，男性和女性尿钴几何均数分别为0.260、0.307μg/L（Z＝-7.35，P＜0.01）；血钼几何均数为0.25μg/L，男性和女性血钼几何均数分别为0.27、0.23μg/L（Z＝-5.03，P＜0.01）；尿钼几何均数为27.7μg/L，男性和女性尿钼几何均数分别为29.8、25.6μg/L（ Z＝-6.31，P＜0.01）。结论我国一般人群血和尿中锰、钴、钼水平存在性别及地区差异。
목적：조사아국일반인군혈화뇨중맹、고、목수평，분석기인군분포특점。방법2009지2010년，재아국동부、서부화중부8개성빈적24개시현，채용정군수궤추양적방법추취료18120명6～60세인군위연구대상，대기생활습관화건강상황진행료문권조사，병분별채집기정맥항응혈양화뇨양。용전감우합등리자체질보법대혈양화뇨양진행맹、고、목함량검측，통과통계학분석불동년령、성별인군혈화뇨중맹、고、목수평적분포。결과아국일반인군혈맹궤하균수위8.98μg/L，남성화녀성혈맹궤하균수분별위8.14、9.88μg/L（Z＝-18.84，P＜0.01）；뇨맹궤하균수위0.63μg/L，남성화녀성뇨맹궤하균수분별위0.62、0.63μg/L（ Z＝-0.67，P＞0.05）；혈고궤하균수위0.194μg/L，남성화녀성혈고궤하균수분별위0.166、0.225μg/L （ Z ＝-23.04， P ＜0.01）；뇨고궤하균수위0.282μg/L，남성화녀성뇨고궤하균수분별위0.260、0.307μg/L（Z＝-7.35，P＜0.01）；혈목궤하균수위0.25μg/L，남성화녀성혈목궤하균수분별위0.27、0.23μg/L（Z＝-5.03，P＜0.01）；뇨목궤하균수위27.7μg/L，남성화녀성뇨목궤하균수분별위29.8、25.6μg/L（ Z＝-6.31，P＜0.01）。결론아국일반인군혈화뇨중맹、고、목수평존재성별급지구차이。
Objective To evaluated the manganese (Mn), cobalt (Co) and molybdenum (Mo) levels in blood and urine among general population in China , and thereby to analyze their prevalent features.Methods From 2009 to 2010, a total of 18 120 subjects of general population aged 6-60 years were recruited from 24 districts in 8 provinces in eastern , central and western China mainland , by cluster random sampling method.The information about their living environment and health status were collected by questionnaire , and their blood and urine samples were also collected.Inductive coupled plasma mass spectrometry ( ICP-MS) was applied to test the Mn , Co and Mo levels of blood and urine samples , and the Mn, Co, Mo distribution in blood and urine among groups of population in different ages and genders were then analyzed.Results Among general population in China , the geometric mean ( GM) of Mn concentration in blood was 8.98 μg/L.The Mn concentration in blood among males and females were separately 8.14 μg/L and 9.88 μg/L ( Z =-18.84, P <0.01 ).The GM of Mn concentration in urine was 0.63 μg/L.The Mn concentration in urine among males and females were separately 0.62 μg/L and 0.63 μg/L ( Z =-0.67, P >0.05 ).The geometric mean ( GM ) of Co concentration in blood was 0.194 μg/L.The Co concentration in blood among males and females were separately 0.166 μg/L and 0.225 μg/L ( Z =-23.04, P <0.01 ).The GM of Co concentration in urine was 0.282 μg/L.The Co concentration in urine among males and females were separately 0.260μg/L and 0.307μg/L ( Z=-7.35, P<0.01).The GM of Mo concentration in blood was 0.25μg/L.The Mo concentration in blood among male and female group were separately 0.27 μg/L and 0.23 μg/L ( Z =-5.03, P <0.01 ).The GM of Mo concentration in urine was 27.7 μg/L.The Mo concentration in urine among males and females were 29.8 μg/L and 25.6μg/L (Z=-6.31,P<0.01), respectively.Conclusion The Mn, Co and Mo levels in blood and urine varied by gender and area among general population in China , the study provided basic data evidence for the following Mn , Co and Mo biological monitoring studies in near future.