中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2014年
16期
32-33
,共2页
复方参芪维E胶囊%泛昔洛韦%带状疱疹%免疫功能
複方參芪維E膠囊%汎昔洛韋%帶狀皰疹%免疫功能
복방삼기유E효낭%범석락위%대상포진%면역공능
Compound Shenqi Vtamin E Capsule%famciclovir%shingles%immune function
目的：探讨复方参芪维 E 胶囊联合泛昔洛韦对带状疱疹患者免疫功能的影响。方法将124例患者随机分为两组，各62例。对照组患者应用泛昔洛韦治疗，同时肌肉注射干扰素α-2b，持续用药7 d；观察组开始用药同对照组，停药后口服复方参芪维 E 胶囊，持续用药10 d。对比分析两组患者临床疗效及症状缓解时间，治疗前后应用流式细胞仪测定两组 T 淋巴细胞亚群。结果观察组总有效率为93.55%，明显高于对照组的77.42%（ P <0.05）。观察组止疱、结痂、疼痛缓解、脱痂时间均明显短于对照组（ P <0.05）。观察组治疗后CD +3，CD4+，CD4+/ CD +8水平显著高于对照组，而CD +8水平则低于对照组（ P <0.05）。观察组后遗神经痛发生率为0（0/62），低于对照组的8.06%（5/62），两组比较有统计学差异（ P <0.05）。结论复方参芪维 E 胶囊联合泛昔洛韦治疗带状疱疹，能有效提高疗效，缓解临床症状，且能有效预防后遗神经痛的发生，同时可提高患者的免疫功能。
目的：探討複方參芪維 E 膠囊聯閤汎昔洛韋對帶狀皰疹患者免疫功能的影響。方法將124例患者隨機分為兩組，各62例。對照組患者應用汎昔洛韋治療，同時肌肉註射榦擾素α-2b，持續用藥7 d；觀察組開始用藥同對照組，停藥後口服複方參芪維 E 膠囊，持續用藥10 d。對比分析兩組患者臨床療效及癥狀緩解時間，治療前後應用流式細胞儀測定兩組 T 淋巴細胞亞群。結果觀察組總有效率為93.55%，明顯高于對照組的77.42%（ P <0.05）。觀察組止皰、結痂、疼痛緩解、脫痂時間均明顯短于對照組（ P <0.05）。觀察組治療後CD +3，CD4+，CD4+/ CD +8水平顯著高于對照組，而CD +8水平則低于對照組（ P <0.05）。觀察組後遺神經痛髮生率為0（0/62），低于對照組的8.06%（5/62），兩組比較有統計學差異（ P <0.05）。結論複方參芪維 E 膠囊聯閤汎昔洛韋治療帶狀皰疹，能有效提高療效，緩解臨床癥狀，且能有效預防後遺神經痛的髮生，同時可提高患者的免疫功能。
목적：탐토복방삼기유 E 효낭연합범석락위대대상포진환자면역공능적영향。방법장124례환자수궤분위량조，각62례。대조조환자응용범석락위치료，동시기육주사간우소α-2b，지속용약7 d；관찰조개시용약동대조조，정약후구복복방삼기유 E 효낭，지속용약10 d。대비분석량조환자림상료효급증상완해시간，치료전후응용류식세포의측정량조 T 림파세포아군。결과관찰조총유효솔위93.55%，명현고우대조조적77.42%（ P <0.05）。관찰조지포、결가、동통완해、탈가시간균명현단우대조조（ P <0.05）。관찰조치료후CD +3，CD4+，CD4+/ CD +8수평현저고우대조조，이CD +8수평칙저우대조조（ P <0.05）。관찰조후유신경통발생솔위0（0/62），저우대조조적8.06%（5/62），량조비교유통계학차이（ P <0.05）。결론복방삼기유 E 효낭연합범석락위치료대상포진，능유효제고료효，완해림상증상，차능유효예방후유신경통적발생，동시가제고환자적면역공능。
Objective To investigate the effect of Compound Shenqi Vitamin E Capsules combined with famciclovir on the immune func-tion in the patients with herpes zoster. Methods 124 cases of herpes zoster were randomly divided into the observation group( n = 62) and the control group( n = 62). The control group simultaneously applied famciclovir and intramuscular injection of interferon for continu-ous 7 d;while at the beginning the medication in the observation group was same to the control group,after drug withdrawal oral Compound Shenqi Vitamin E Capsules was given for continuous 10 d. The clinical effects and the symptom remission time were com-pared between the two groups. The levels of CD4+ T lymphocyte subsets before and after treatment in the two groups were detected by the flow cytometry. Results The total effective rate of observation group was 93. 55% ,which was higher than 77. 42% in the control group,the difference had statistical significance( P < 0. 05). The time of blister stop,crusting time,pain relief time and decrustation time in the observation group were shorter than those in the control group( P < 0. 05). The levels of CD +3 ,CD4+ and CD4+ / CD +8 in the ob-servation group were significantly higher than those in the control group,while the level of CD +8 was lower than that in the control group( P < 0. 05). The incidence rate of postherpetic neuralgia in observation group was 0. 00%(0 / 62),which was lower than 8. 06%(5 / 62)in the control group,there was statistically significant difference between the two groups( P < 0. 05). Conclusion Compound Shenqi Vtamin E Capsule combined with famciclovir in treating herpes zoster can improve the curative effect,alleviate the clinical symptoms,effectively prevent the occurrence of postherpetic neuralgia and simultaneously increase the patient’s immune function.
