CAJ | 학술논문

目的：探讨磷霉素联合其他抗菌药物的时间差疗法治疗难治性肺炎的疗效，并分析磷霉素的作用特点。方法将126例难治性肺炎患者随机分为 A 组、B 组，各63例。A 组采用磷霉素联合其他抗菌药物的时间差疗法，B 组采用磷霉素联合其他抗菌药物的传统序贯疗法。结果 A 组的治愈率为92.06%，B 组为76.19%；A 组平均起效时间、平均治愈时间及细菌清除率均优于 B 组（ P <0.05）。结论磷霉素联合其他抗菌药物的时间差疗法治疗难治性肺炎安全有效，不良反应少且轻微。
목적：탐토린매소연합기타항균약물적시간차요법치료난치성폐염적료효，병분석린매소적작용특점。방법장126례난치성폐염환자수궤분위 A 조、B 조，각63례。A 조채용린매소연합기타항균약물적시간차요법，B 조채용린매소연합기타항균약물적전통서관요법。결과 A 조적치유솔위92.06%，B 조위76.19%；A 조평균기효시간、평균치유시간급세균청제솔균우우 B 조（ P <0.05）。결론린매소연합기타항균약물적시간차요법치료난치성폐염안전유효，불량반응소차경미。
Objective To investigate the effect of the time difference therapy of fosfomycin combined with other antibacterial drugs in the treatment of refractory pneumonia and to analyze the characteristics of phosphomycin. Methods 126 patients with refractory pneu-monia were randomly divided into the group A and B,63 cases in each group. The group A was treated by the time difference therapy of fosfomycin in combination with other antibacterial agents,while the group B adopted the traditional sequential therapy of fosfomycin in combination with other antibiotics. Results The cure rate was 92. 06% in the group A and 76. 19% in the group B;the average initial effect time,cure time and the bacterial clearance rate in the group A were superior to those in the group B with statistical dif-ferences( P < 0. 05). Conclusion The time difference therapy of fosfomycin combined with other antibacterial drugs is safe and effec-tive and has few and mild adverse reaction for treating refractory pneumonia.