CAJ | 학술논문

以橙花叔醇、原乙酸三甲酯为原料、丁酸为催化剂、在130～150℃条件下，经酯交换、重排反应、得到法呢基乙酸甲酯顺反异构体，后在氢氧化钾的条件下水解、蒸干得法呢基乙酸钾盐顺反异构体、再以乙酸乙酯为溶剂结晶分离、酸化、得到4，8-E-法呢基乙酸，与香叶醇缩合得到4，8-E-法呢基乙酸香叶酯。该法操作简单，条件温和、总收率为27.6％。
이등화숙순、원을산삼갑지위원료、정산위최화제、재130～150℃조건하，경지교환、중배반응、득도법니기을산갑지순반이구체，후재경양화갑적조건하수해、증간득법니기을산갑염순반이구체、재이을산을지위용제결정분리、산화、득도4，8-E-법니기을산，여향협순축합득도4，8-E-법니기을산향협지。해법조작간단，조건온화、총수솔위27.6％。
Nerolidol and trimethyl orthoacetate was used as starting material to give farnesylacetic acid by esterification , rearrangement reaction between 130~150℃in the presence of butyric acid.Farnesyl acetate potassium cis and trans isomers was obtained via hydrolysis reaction in the condition of potassium hydroxide.Following by crystallization separation in ethyl acetate and acidification , condensation with geraniol the title compund 4 , 8 -E -farnesyl geranyl acetate was achieved.This method was simple , the reaction conditions were mild , and the total yield was 27.6%.