CAJ | 학술논문

固相研磨有机合成方法比传统的有机合成方法方便，易操作。在研磨条件下许多传统的反应可以在较温和的条件下进行，能有效的提高收率或反应的选择性。本文主要综述了固相研磨反应在Knoevenagel 缩合、醇醛缩合、 wittig缩合、 Biginelli缩合、希夫碱缩合等缩合反应中的应用。
고상연마유궤합성방법비전통적유궤합성방법방편，역조작。재연마조건하허다전통적반응가이재교온화적조건하진행，능유효적제고수솔혹반응적선택성。본문주요종술료고상연마반응재Knoevenagel 축합、순철축합、 wittig축합、 Biginelli축합、희부감축합등축합반응중적응용。
Compared with the traditional methodology , solid phase grinding method can be operated conveniently and easily.With solid phase grinding method , some traditional organic reaction can be performed under mild condition in higher yield or in better selectivity.The applications of solid phase grinding method in Knoevenagel condensation , aldol reaction, wittig reaction , Biginelli condensation and Schiff base condensation reaction were highlighted.