CAJ | 학술논문

核因子 E2相关因子2（Nrf2）是一种调控氧化应激基本表达的关键转录因子，以 Kelch样环氧氯丙烷相关蛋白-1（Keap1）在氧化环境下的构象改变或者其本身直接被磷酸化而激活并进入细胞核与抗氧化反应元件（ARE）结合，启动 ARE 下游的一系列抗氧化基因的转录、表达以抵抗机体内外界的有害刺激。本文主要总结了 Nrf2信号途径的特点及其在动物机体抗氧化过程中的重要作用，并结合它在畜禽抗应激、肉品质、新型饲料添加剂和保健品等开发方面的应用，阐述了其在维持畜禽健康和肉品质中的重要作用。
핵인자 E2상관인자2（Nrf2）시일충조공양화응격기본표체적관건전록인자，이 Kelch양배양록병완상관단백-1（Keap1）재양화배경하적구상개변혹자기본신직접피린산화이격활병진입세포핵여항양화반응원건（ARE）결합，계동 ARE 하유적일계렬항양화기인적전록、표체이저항궤체내외계적유해자격。본문주요총결료 Nrf2신호도경적특점급기재동물궤체항양화과정중적중요작용，병결합타재축금항응격、육품질、신형사료첨가제화보건품등개발방면적응용，천술료기재유지축금건강화육품질중적중요작용。
Nuclear factor erythroid-2-related factor 2(Nrf2)is an important molecule in antioxidative and red-ox signaling. Nrf2 can be activated by conformational change of Keap1 or Nrf2 itself phosphorylation. The acti-vated Nrf2 enters the nucleus and binds with antioxidant response element( ARE)to transactivate the expres-sion of a series of antioxidant enzyme genes against the harmful stimuli. This review summarizes Nrf2-mediated antioxidant pathway and its regulatory role in anti-stress,meat quality,development of feed additives,and the impact in maintaining the health of livestock and poultry.