化学研究与应用
化學研究與應用
화학연구여응용
CHEMICAL RESEARCH AND APPLICATION
2014年
7期
1095-1098
,共4页
张齐华%容元伟%高勇%张喜全%顾红梅%李宝林
張齊華%容元偉%高勇%張喜全%顧紅梅%李寶林
장제화%용원위%고용%장희전%고홍매%리보림
2 ,3 ,4 ,6-O-四苄基-D-葡萄糖%双还原胺化%四苄基米格列醇%米格列醇
2 ,3 ,4 ,6-O-四芐基-D-葡萄糖%雙還原胺化%四芐基米格列醇%米格列醇
2 ,3 ,4 ,6-O-사변기-D-포도당%쌍환원알화%사변기미격렬순%미격렬순
2,3,4,6-tetra-O-benzyl-glucopyranose%double reductive amination%N-(2-hydroxy-ethyl)-2,3,4,6-tetra-O-benzyl-1-deoxynojirimycin%miglitol
以2,3,4,6-O-四苄基-D-葡萄糖为原料,经还原,Swern氧化,双还原胺化,催化氢解脱苄基得米格列醇,四步反应总收率为50%。该过程首次用乙醇胺直接与四苄基葡萄糖二羰基衍生物进行双还原胺化反应合成了米格列醇,是一条合成米格列醇的新路线。所得化合物的结构通过1 H-NMR,13 C-NMR和MS进行确证。
以2,3,4,6-O-四芐基-D-葡萄糖為原料,經還原,Swern氧化,雙還原胺化,催化氫解脫芐基得米格列醇,四步反應總收率為50%。該過程首次用乙醇胺直接與四芐基葡萄糖二羰基衍生物進行雙還原胺化反應閤成瞭米格列醇,是一條閤成米格列醇的新路線。所得化閤物的結構通過1 H-NMR,13 C-NMR和MS進行確證。
이2,3,4,6-O-사변기-D-포도당위원료,경환원,Swern양화,쌍환원알화,최화경해탈변기득미격렬순,사보반응총수솔위50%。해과정수차용을순알직접여사변기포도당이탄기연생물진행쌍환원알화반응합성료미격렬순,시일조합성미격렬순적신로선。소득화합물적결구통과1 H-NMR,13 C-NMR화MS진행학증。
Miglitol were synthesized from 2,3,4,6-tetra-O-benzyl-glucopyranose as a starting material by four-step reactions inclu-ding reduction,swern oxidation,double reductive amination and catalyzed hydrogenolysis with an overall yield of 50%. This method used 2-aminoethanol to react with 1,5-dicarbonyl derivative of tetrabenzyl glucose directly in double reductive amination. The struc-tures of synthesized compounds were identified by 1 H-NMR and 13 C-NMR spectroscopy etc.
