CAJ | 학술논문

目的：探讨ABCD2评分联合血清高敏C反应蛋白（ hs-CRP）检测对短暂性脑缺血发作（ TIA）患者1个月内发生急性脑卒中的预测价值。方法回顾性分析神经内科2011年11月-2013年10收治的TIA患者121例，其中1个月内发生急性脑卒中者35例作为卒中组，未发生者86例作为对照组。分析2组患者ABCD2评分及血清hs-CRP水平的差异，及其预测患者1个月内发生急性脑卒中的价值。结果卒中组患者ABCD2评分高于对照组[（6'．1±1．2）分vs．（4．2±1．6）分]，高危患者比例显著高于对照组（94．3％vs．2．4％），差异均有统计学意义（ P ＜0．05）；卒中组hs-CRP水平为（23．71±4．56）mg/L，高于对照组的（11．48±3．88）mg/L（ P ＜0．05）；TIA患者hs-CRP水平与ABCD2评分呈正相关（ r ＝0．56， P ＜0．05）；以患者血清hs-CRP作为预测TIA患者在1个月内发生急性脑卒中的指标，其ROC曲线下面积为0．86（95％CI 0．79～0．93），以16．78 mg/L为cut-off值，其预测TIA发生急性脑卒中的敏感度为80．7％、特异度为60．8％。结论近期发生急性脑卒中的TIA患者ABCD2评分及血浆hs-CRP均显著升高，ABCD2评分及hs-CRP检测可作为预测TIA患者近期发生脑卒中的重要指标。
목적：탐토ABCD2평분연합혈청고민C반응단백（ hs-CRP）검측대단잠성뇌결혈발작（ TIA）환자1개월내발생급성뇌졸중적예측개치。방법회고성분석신경내과2011년11월-2013년10수치적TIA환자121례，기중1개월내발생급성뇌졸중자35례작위졸중조，미발생자86례작위대조조。분석2조환자ABCD2평분급혈청hs-CRP수평적차이，급기예측환자1개월내발생급성뇌졸중적개치。결과졸중조환자ABCD2평분고우대조조[（6'．1±1．2）분vs．（4．2±1．6）분]，고위환자비례현저고우대조조（94．3％vs．2．4％），차이균유통계학의의（ P ＜0．05）；졸중조hs-CRP수평위（23．71±4．56）mg/L，고우대조조적（11．48±3．88）mg/L（ P ＜0．05）；TIA환자hs-CRP수평여ABCD2평분정정상관（ r ＝0．56， P ＜0．05）；이환자혈청hs-CRP작위예측TIA환자재1개월내발생급성뇌졸중적지표，기ROC곡선하면적위0．86（95％CI 0．79～0．93），이16．78 mg/L위cut-off치，기예측TIA발생급성뇌졸중적민감도위80．7％、특이도위60．8％。결론근기발생급성뇌졸중적TIA환자ABCD2평분급혈장hs-CRP균현저승고，ABCD2평분급hs-CRP검측가작위예측TIA환자근기발생뇌졸중적중요지표。
Objective To investigate the predictive value of ABCD 2 score combined with serum high-sensitivity C-reactive protein ( hs-CRP) detection of transient ischemic attack ( TIA) patients within a month of acute stroke .Methods Retrospective analysis of 121 patients with TIA who admitted to department of neurology from November 2011 to October 2013 , 35 cases of acute stroke were occurred within a month as stroke group , 86 cases did not occur as the control group .Analysis of differences of two groups'patient ABCD2 score and serum hs-CRP levels , and their predictive value in patients occurred within a month of acute stroke.Results ABCD2 score was higher in stroke patients [(6.1 ±1.2) points vs.(4.2 ±1.6) points ],the proportion of high-risk patients was significantly higher (94.3% vs.2.4%),the differences were statistically significant ( P <0.05); stroke group hs-CRP levels (23.71 ±4.56) mg/L,was higher than the control group (11.48 ± 3.88) mg/L ( P <0.05);TIA patients'hs-CRP levels and ABCD2 score was positively correlated ( r =0.56, P <0.05);serum hs-CRP as a predictor of acute stroke within a month in TIA patients with the area under the ROC curve of 0.86 (95%CI 0.79-0.93), as 16.78 mg /L to be the cut off value, the prediction of acute stroke in TIA patients as sensitivity of 80. 7%, specificity of 60.8 %.Conclusion Recent acute stroke ABCD2 score and plasma hs-CRP were significantly higher in patients with TIA , ABCD2 score and hs-CRP detection can be important predictors of stroke in patients with recent TIA .