CAJ | 학술논문

目的：探讨厄贝沙坦氢氯噻嗪片（安博诺）治疗老年单纯性收缩期高血压患者的临床效果。方法2010年1月-2012年12月诊治、符合入组标准的老年单纯性收缩期高血压患者78例，随机分为2组，其中接受安博诺治疗的患者为观察组（39例，剔除4例），接受依那普利联合氢氯噻嗪联合降压治疗的患者为对照组（39例，剔除3例）。观察2组患者临床治疗疗效、血压、脉压及电解质变化情况并进行比较，同时记录不良反应。结果观察组患者总有效率为91*．4％（32/35），与对照组的91．6％（33/36）比较无明显差异（ P ＞0．05）。2组患者的收缩压、舒张压及脉压差均随着时间延长而逐渐下降，但2组2、4、6、8周组内比较差异无统计学意义（ P ＞0．05）；与治疗前比较，2组治疗后3个指标均显著改善（对照组治疗后2周舒张压除外， P ＜0．05）。2组患者心率比较亦未见无明显的变化（P ＞0．05）。除对照组治疗后血K＋水平轻度下降外（ P ＜0．05），2组治疗前后电解质、肝肾功能无明显变化（ P ＞0．05）。观察组不良事件发生率为5．7％（2/35），对照组不良事件发生率为8．3％（3/36），差异亦无统计学意义（P ＞0．05）。结论安博诺治疗老年单纯性收缩期高血压能够有效控制血压，临床疗效显著，不良反应发生率低，值得临床推广应用。
목적：탐토액패사탄경록새진편（안박낙）치료노년단순성수축기고혈압환자적림상효과。방법2010년1월-2012년12월진치、부합입조표준적노년단순성수축기고혈압환자78례，수궤분위2조，기중접수안박낙치료적환자위관찰조（39례，척제4례），접수의나보리연합경록새진연합강압치료적환자위대조조（39례，척제3례）。관찰2조환자림상치료료효、혈압、맥압급전해질변화정황병진행비교，동시기록불량반응。결과관찰조환자총유효솔위91*．4％（32/35），여대조조적91．6％（33/36）비교무명현차이（ P ＞0．05）。2조환자적수축압、서장압급맥압차균수착시간연장이축점하강，단2조2、4、6、8주조내비교차이무통계학의의（ P ＞0．05）；여치료전비교，2조치료후3개지표균현저개선（대조조치료후2주서장압제외， P ＜0．05）。2조환자심솔비교역미견무명현적변화（P ＞0．05）。제대조조치료후혈K＋수평경도하강외（ P ＜0．05），2조치료전후전해질、간신공능무명현변화（ P ＞0．05）。관찰조불량사건발생솔위5．7％（2/35），대조조불량사건발생솔위8．3％（3/36），차이역무통계학의의（P ＞0．05）。결론안박낙치료노년단순성수축기고혈압능구유효공제혈압，림상료효현저，불량반응발생솔저，치득림상추엄응용。
Objective To investigate the clinical effect of coaprovel in the treatment of elder patients with isolated systolic hypertension ( ISH) .Methods From January 2010 to December2012 ,elderly patients meets the standard of diagnosis and treatment of isolated systolic hypertension (78 cases) were randomly divided into 2 groups, observation group were re-ceived the Abono treatment (39 cases, 4 cases were excluded), control group were received enalapril and hydrochlorothiazide combination therapy (39 cases, 3 cases were excluded).Clinical curative effect, blood pressure, pulse pressure and electro-lyte changes and adverse reactions of 2 groups of patients were recorded and compared .Results Patients in the observation group's total effective rate was 91.4%(32/35), and in control group was 91.6%(33/36), there were no significant differ-ences ( P >0.05).2 groups of patients with systolic pressure , diastolic pressure and pulse pressure increased along with the time increased, but the 2 groups'2,4, 6, 8 weeks intra -group comparison revealed no significant difference ( P>0.05);compared with before treatment , after 2,4,6,8 weeks treatment, three indicators of the 2 groups were significantly improved (except DBP after 2 weeks in control group, P <0.05).Heart rate of the2 groups of patients also had no obvious change (P >0.05).After treatment, except the control group's blood K+level was mild declined ( P <0.05), before and after treatment, electrolyte, liver and kidney function of the 2 groups had no significant changes ( P >0.05).The observation group's incidence of adverse events was 5.7%(2/35), the control group's incidence of adverse events was 8.3% (3/36), the difference had no statistical significance ( P >0.05).Conclusion In the treatment of elder ISH patients ,coaprovel can effectively control blood pressure,had great curative effects ,the adverse reactions rate was low.Hence ,it was worthy of clinical promotion.