中国医药导刊
中國醫藥導刊
중국의약도간
CHINESE JOURNAL OF MEDICAL GUIDE
2014年
6期
1012-1013
,共2页
王庆%陈光虎%尹红霞%蔡鲜
王慶%陳光虎%尹紅霞%蔡鮮
왕경%진광호%윤홍하%채선
补佳乐%回奶%最低有效量
補佳樂%迴奶%最低有效量
보가악%회내%최저유효량
Estradial valerate%Postpartum lactation%The lowest effective dose
目的：探讨戊酸雌二醇片(补佳乐)在产后回奶中的最低有效剂量。方法：将产后来院要求回奶的产妇150例随机分为5组,观察Ⅰ组给予补佳乐5mg,每日3次,连服5d。观察Ⅱ组给予补佳乐2mg,每日3次,首剂加倍,连服5d。观察Ⅲ组给予补佳乐1mg,每日3次,首剂加倍,连服5d。对照组Ⅰ组给予己烯雌酚,每次5mg,每日3次,连服5d。对照组Ⅱ组给予溴隐亭口服,每次2.5mg,每日2次,连服5日。结果：观察Ⅰ、Ⅱ组有效率与己烯雌酚组及溴隐亭组相比差异无统计学意义(P>0.05)。观察Ⅰ、Ⅱ组之间相比差异无统计学意义(P>0.05)。观察Ⅰ组、观察Ⅱ组、对照Ⅰ组、对照Ⅱ组回奶效果均显著高于补佳乐Ⅲ组(P<0.05)。与已烯雌酚组及溴隐亭组比较补佳乐各组胃肠道反应发生率显著降低(P<0.05),观察Ⅰ组与观察Ⅱ组剂相较回奶效果差异无统计学意义(P>0.05)。结论：补佳乐退奶理想,且补佳乐2mg,每日3次,首剂加倍为补佳乐退奶的最佳有效剂量。
目的：探討戊痠雌二醇片(補佳樂)在產後迴奶中的最低有效劑量。方法：將產後來院要求迴奶的產婦150例隨機分為5組,觀察Ⅰ組給予補佳樂5mg,每日3次,連服5d。觀察Ⅱ組給予補佳樂2mg,每日3次,首劑加倍,連服5d。觀察Ⅲ組給予補佳樂1mg,每日3次,首劑加倍,連服5d。對照組Ⅰ組給予己烯雌酚,每次5mg,每日3次,連服5d。對照組Ⅱ組給予溴隱亭口服,每次2.5mg,每日2次,連服5日。結果：觀察Ⅰ、Ⅱ組有效率與己烯雌酚組及溴隱亭組相比差異無統計學意義(P>0.05)。觀察Ⅰ、Ⅱ組之間相比差異無統計學意義(P>0.05)。觀察Ⅰ組、觀察Ⅱ組、對照Ⅰ組、對照Ⅱ組迴奶效果均顯著高于補佳樂Ⅲ組(P<0.05)。與已烯雌酚組及溴隱亭組比較補佳樂各組胃腸道反應髮生率顯著降低(P<0.05),觀察Ⅰ組與觀察Ⅱ組劑相較迴奶效果差異無統計學意義(P>0.05)。結論：補佳樂退奶理想,且補佳樂2mg,每日3次,首劑加倍為補佳樂退奶的最佳有效劑量。
목적：탐토무산자이순편(보가악)재산후회내중적최저유효제량。방법：장산후래원요구회내적산부150례수궤분위5조,관찰Ⅰ조급여보가악5mg,매일3차,련복5d。관찰Ⅱ조급여보가악2mg,매일3차,수제가배,련복5d。관찰Ⅲ조급여보가악1mg,매일3차,수제가배,련복5d。대조조Ⅰ조급여기희자분,매차5mg,매일3차,련복5d。대조조Ⅱ조급여추은정구복,매차2.5mg,매일2차,련복5일。결과：관찰Ⅰ、Ⅱ조유효솔여기희자분조급추은정조상비차이무통계학의의(P>0.05)。관찰Ⅰ、Ⅱ조지간상비차이무통계학의의(P>0.05)。관찰Ⅰ조、관찰Ⅱ조、대조Ⅰ조、대조Ⅱ조회내효과균현저고우보가악Ⅲ조(P<0.05)。여이희자분조급추은정조비교보가악각조위장도반응발생솔현저강저(P<0.05),관찰Ⅰ조여관찰Ⅱ조제상교회내효과차이무통계학의의(P>0.05)。결론：보가악퇴내이상,차보가악2mg,매일3차,수제가배위보가악퇴내적최가유효제량。
Investigate the lowest effective dose of estradial valerate in postpartum lactation.Methods:Divided randomly the 150 parturients demanding to lactation into 5 groups,observation groupⅠgiven estradiol valerate 5mg,3 times a day,and even served 5d.Observation groupⅡwas given orally 2mg,3 times a day,double dose at first,even for 5d. Observation groupⅢgiven progynova 1mg,3 times a day,double dose at first,even for 5d.The control groupⅠwas treated with diethylstilbestrol,5mg each time,3 times a day,and even served 5d.The control groupⅡgroup was treated with bromocriptine orally,2.5mg each time,2 times a day,and even served 5 days.Results:There was no significant difference (P>0.05) in efficiency among observation groupⅠand observation groupⅡand diethylstilbestrol group and bromocriptine group.There was no significant difference (P>0.05) in between observation groupⅠand observation groupⅡ.Observation of I group,observation groupⅡ,control group,control groupⅡto lactation the effect was significantly higher than that of progynova groupⅢ(P<0.05).Compare with diethylstilbestrol group and the bromocriptine group,the gastrointestinal reaction of observation groups were significantly lower (P<0.05).GroupⅠandⅡgroup were observed compared to lactation agent effect was not statistically significant (P>0.05).Conclusion:Estradiol valerate in 2mg,3 times a day,double dose at first that is the best effective dose in returning lactation.
