癌症进展
癌癥進展
암증진전
ONCOLOGY PROGRESS
2014年
3期
272-277
,共6页
张雯杰%吴宁%王成锋%石素胜%郑容%李小萌%张翰%梁颖%刘瑛%赵平
張雯傑%吳寧%王成鋒%石素勝%鄭容%李小萌%張翰%樑穎%劉瑛%趙平
장문걸%오저%왕성봉%석소성%정용%리소맹%장한%량영%류영%조평
胰腺癌%氟脱氧葡萄糖%标准摄取值%血管内皮生长因子%微血管密度
胰腺癌%氟脫氧葡萄糖%標準攝取值%血管內皮生長因子%微血管密度
이선암%불탈양포도당%표준섭취치%혈관내피생장인자%미혈관밀도
pancreatic cancer%fluorodeoxyglucose%standardized uptake value%VEGF%MVD
目的：初步探讨胰腺癌病灶的18 F-FDG摄取程度( SUV)与手术切除标本的血管内皮生长因子( VEGF)表达及微血管密度( MVD)之间的关系，考察SUV是否能够于疗前在体评估胰腺癌的血管生成状态。方法纳入2008年5月至2011年9月于我科行PET-CT检查后行手术切除的10例胰腺导管腺癌患者，术前均未行放疗或化疗。记录PET-CT图像中病灶的最大标准摄取值( SUVmax )，并使用免疫组织化学染色检查胰腺癌标本的MVD及VEGF表达。结果10例胰腺癌病灶的中位SUVmax为4．7(3．3~5．9)，中位 MVD为67(49~110)， VEGF (-)4例， VEGF (+)3例， VEGF (++)3例。取中位SUVmax=4．7为界值点分组对比可知， VEGF (++)患者的SUVmax高于VEGF (+)/(-)患者，且MVD计数较高与SUVmax偏高存在一定正相关趋势。结论本组小样本结果初步表明，胰腺导管腺癌的SUVmax越高，发生转移的可能性越大。 SUVmax与VEGF表达和MVD计数存在正相关趋势的可能，初步提示18 F-FDG PET-CT检查有可能于疗前在体评估胰腺癌的血管生成状态，有望为临床是否行分子靶向治疗提供更多有价值的信息。
目的：初步探討胰腺癌病竈的18 F-FDG攝取程度( SUV)與手術切除標本的血管內皮生長因子( VEGF)錶達及微血管密度( MVD)之間的關繫，攷察SUV是否能夠于療前在體評估胰腺癌的血管生成狀態。方法納入2008年5月至2011年9月于我科行PET-CT檢查後行手術切除的10例胰腺導管腺癌患者，術前均未行放療或化療。記錄PET-CT圖像中病竈的最大標準攝取值( SUVmax )，併使用免疫組織化學染色檢查胰腺癌標本的MVD及VEGF錶達。結果10例胰腺癌病竈的中位SUVmax為4．7(3．3~5．9)，中位 MVD為67(49~110)， VEGF (-)4例， VEGF (+)3例， VEGF (++)3例。取中位SUVmax=4．7為界值點分組對比可知， VEGF (++)患者的SUVmax高于VEGF (+)/(-)患者，且MVD計數較高與SUVmax偏高存在一定正相關趨勢。結論本組小樣本結果初步錶明，胰腺導管腺癌的SUVmax越高，髮生轉移的可能性越大。 SUVmax與VEGF錶達和MVD計數存在正相關趨勢的可能，初步提示18 F-FDG PET-CT檢查有可能于療前在體評估胰腺癌的血管生成狀態，有望為臨床是否行分子靶嚮治療提供更多有價值的信息。
목적：초보탐토이선암병조적18 F-FDG섭취정도( SUV)여수술절제표본적혈관내피생장인자( VEGF)표체급미혈관밀도( MVD)지간적관계，고찰SUV시부능구우료전재체평고이선암적혈관생성상태。방법납입2008년5월지2011년9월우아과행PET-CT검사후행수술절제적10례이선도관선암환자，술전균미행방료혹화료。기록PET-CT도상중병조적최대표준섭취치( SUVmax )，병사용면역조직화학염색검사이선암표본적MVD급VEGF표체。결과10례이선암병조적중위SUVmax위4．7(3．3~5．9)，중위 MVD위67(49~110)， VEGF (-)4례， VEGF (+)3례， VEGF (++)3례。취중위SUVmax=4．7위계치점분조대비가지， VEGF (++)환자적SUVmax고우VEGF (+)/(-)환자，차MVD계수교고여SUVmax편고존재일정정상관추세。결론본조소양본결과초보표명，이선도관선암적SUVmax월고，발생전이적가능성월대。 SUVmax여VEGF표체화MVD계수존재정상관추세적가능，초보제시18 F-FDG PET-CT검사유가능우료전재체평고이선암적혈관생성상태，유망위림상시부행분자파향치료제공경다유개치적신식。
Objective To preliminarily investigate the relationship between 18 F-FDG uptake and VEGF as well as MVD in resected specimens of pancreatic cancer, and to find out whether 18 F-FDG uptake can assess tumor angiogenesis in vivo. Method From May 2008 to September 2011, 10 patients with resected pancreatic ductal adenocarcinoma, who had underg-one preoperative 18 F-FDG PET-CT scan without prior chemotherapy or radiotherapy, were enrolled in this study. The PET-CT data was used to calculate tumor maximum SUV (SUVmax). With resected tumor specimens, VEGF and intratumoral MVD expression level were assessed using immunohistochemical staining. Result In the 10 patients included in the study, the median SUVmax was 4. 7 (3. 3~5. 9), and median MVD was 67 (49~110). Four patients had VEGF (-), 3 had VEGF (+) and 3 had VEGF (++). Setting median SUVmax=4. 7 as the cut-off value for grouping, we found that patients with VEGF (++) had higher SUVmax than those with VEGF (+) / (-), and higher MVD was likely correlated to increased SUVmax . Conclusion The small sample research of 10 patients indicates that in patients with pancreatic ductal adenocarcino-ma, higher SUVmax of primary tumor suggests more likely occurrence of metastases. There is a possible tendency of positive correlation between SUVmax and VEGF, as well as MVD. The preliminary results suggest that 18 F-FDG PET-CT may be ap-plied to assess the angiogenesis in vivo and offer more valuable information for clinical molecular-targeted therapy.
