CAJ | 학술논문

采用Meta分析的方法探讨中国人近视与原发性开角型青光眼（ POAG）的相关性。方法检索CNKI和VIP数据库中自建库至2013年7月20日之间公开发表的文献，对符合纳入标准的研究进行数据提取之后，采用Comprehensive Meta Analysis （ CMA） v2．2软件进行 Meta分析。结果最终纳入5个研究，其中3个研究将高度近视作为暴露因素单独列出来。 Meta分析结果显示，暴露于近视的人群罹患POAG的风险增加3．07倍（OR ＝3．07，95％CI ＝1．90～4．96；P ＜0．01）；暴露于高度近视者（屈光度数＞-6．0 D），罹患POAG的风险增加7．15倍（OR ＝7．15，95％CI ＝4．01～12．75；P ＜0．01）。敏感性分析显示结果稳健性好，未行发表偏倚分析。结论当前证据表明近视很可能是开角型青光眼的一个独立的、有意义的危险因素，并且高度近视者罹患POAG的风险高。
채용Meta분석적방법탐토중국인근시여원발성개각형청광안（ POAG）적상관성。방법검색CNKI화VIP수거고중자건고지2013년7월20일지간공개발표적문헌，대부합납입표준적연구진행수거제취지후，채용Comprehensive Meta Analysis （ CMA） v2．2연건진행 Meta분석。결과최종납입5개연구，기중3개연구장고도근시작위폭로인소단독렬출래。 Meta분석결과현시，폭로우근시적인군리환POAG적풍험증가3．07배（OR ＝3．07，95％CI ＝1．90～4．96；P ＜0．01）；폭로우고도근시자（굴광도수＞-6．0 D），리환POAG적풍험증가7．15배（OR ＝7．15，95％CI ＝4．01～12．75；P ＜0．01）。민감성분석현시결과은건성호，미행발표편의분석。결론당전증거표명근시흔가능시개각형청광안적일개독립적、유의의적위험인소，병차고도근시자리환POAG적풍험고。
Objective To explore the association between myopia and primary open angle glaucoma ( POAG) by Meta-analysis.Methods Relevant studies, published up to July 20, 2013, were searched from CNKI and VIP databases . After data extraction, a meta-analysis was performed using CMA (comprehensive meta analysis) v2.2 software.Results Five studies were finally recruited , including 3 studies that reported the association between myopia and POAG independ-ently.The results of meta-analysis showed that myopia evidently increases the risk of POAG by 3.07 times ( OR=3.07, 95%CI=1.90~4.96), and high myopia obviously increases the risk of POAG by 7.15 times (OR=7.15, 95% CI=4.01~12.75).Sensitivity analysis showed that the results were robust .The publication bias analysis was not conducted . Conclusion Based on the current evidence , myopia is probably an independent and significant risk factor for POAG , and the high myopia persons were with higher risk for POAG .