CAJ | 학술논문

目的：探讨放疗联合华蟾素片治疗老年中晚期非小细胞肺癌(NSCLC)的临床疗效。方法按照随机数字表法将50例老年中晚期NSCLC患者分为实验组和对照组，实验组患者给予放疗联合华蟾素片治疗，对照组患者仅给予放疗，比较两组患者近期疗效、远期疗效以及治疗期间不良反应发生情况。结果实验组患者部分缓解率和总有效率均显著高于对照组，差异具有统计学意义（P＜0.05）；实验组患者不良反应发生情况均低于对照组，其中白细胞下降、恶心、呕吐和胸痛发生率具有统计学差异（P＜0.05）；实验组患者2年生存率和平均生存时间均显著高于对照组，差异具有统计学意义（P＜0.05）。结论在常规放疗基础上加用华蟾素片能够有效提高中晚期NSCLC治疗效果，降低不良反应发生率，延长患者生存时间，疗效显著。
목적：탐토방료연합화섬소편치료노년중만기비소세포폐암(NSCLC)적림상료효。방법안조수궤수자표법장50례노년중만기NSCLC환자분위실험조화대조조，실험조환자급여방료연합화섬소편치료，대조조환자부급여방료，비교량조환자근기료효、원기료효이급치료기간불량반응발생정황。결과실험조환자부분완해솔화총유효솔균현저고우대조조，차이구유통계학의의（P＜0.05）；실험조환자불량반응발생정황균저우대조조，기중백세포하강、악심、구토화흉통발생솔구유통계학차이（P＜0.05）；실험조환자2년생존솔화평균생존시간균현저고우대조조，차이구유통계학의의（P＜0.05）。결론재상규방료기출상가용화섬소편능구유효제고중만기NSCLC치료효과，강저불량반응발생솔，연장환자생존시간，료효현저。
Objective To explore the clinical effects for the patients with NSCLC by radiotherapy combine with HuaChan tablet. Methods 50 cases of patients with NSCLC were randomly divided into experiment group and control group. The experiment group were treated by radiotherapy combine with HuaChan tablet, the control group were treated by radiotherapy. The clinical effects were compared for the two groups. Results The rate of PR and total effective rate for the experiment group were higher than the control group(P < 0.05); The complication for the experiment group were lower than the control group(P<0.05), the rate of white blood cells decline, nausea, throw up, chest pain for the experiment group were lower than the control group(P<0.05); The survival rate of two years and mean survival time for the experiment group were higher than the control group(P<0.05). Conclusion The clinical effects for the patients with NSCLC by radiotherapy combine with HuaChan tablet is good, it can reduce the rate of complication, extended lifetime , the clinical effects is significant difference.