CAJ | 학술논문

目的：探讨自体造血干细胞移植（ASCT）后早期正电子发射计算机断层显像-电子计算机X射线断层扫描技术（PET-CT）检查对难治、复发的霍奇金淋巴瘤（HL）患者预后的意义。方法选取本院2007年11月至2013年3月收治的12例行ASCT的HL患者作为研究对象，回顾性分析其行ASCT后1个月PET-CT检查中最大标准摄取值（SUV值）与预后的相关性。结果挽救性化疗后完全缓解6例，部分缓解4例，难治2例。移植后完全缓解7例，部分缓解3例，难治2例。到最后随访时，9例（75.0%）患者生存，3例（16.3%）患者死于疾病进展。行ASCT后1个月PET-CT检查阳性3例。移植后PET-CT扫描阴性组总体生存率[83.3%（10/12）]及无进展生存率[75.0%（9/12）]明显优于阳性组[33.3%（4/12）、0]，差异均有统计学意义（P＜0.05）。结论 PET-CT可以作为ASCT的预后指标。
목적：탐토자체조혈간세포이식（ASCT）후조기정전자발사계산궤단층현상-전자계산궤X사선단층소묘기술（PET-CT）검사대난치、복발적곽기금림파류（HL）환자예후적의의。방법선취본원2007년11월지2013년3월수치적12례행ASCT적HL환자작위연구대상，회고성분석기행ASCT후1개월PET-CT검사중최대표준섭취치（SUV치）여예후적상관성。결과만구성화료후완전완해6례，부분완해4례，난치2례。이식후완전완해7례，부분완해3례，난치2례。도최후수방시，9례（75.0%）환자생존，3례（16.3%）환자사우질병진전。행ASCT후1개월PET-CT검사양성3례。이식후PET-CT소묘음성조총체생존솔[83.3%（10/12）]급무진전생존솔[75.0%（9/12）]명현우우양성조[33.3%（4/12）、0]，차이균유통계학의의（P＜0.05）。결론 PET-CT가이작위ASCT적예후지표。
Objective To investigate the prognostic role of early positrone mission tomography-computed tomography (PET-CT)examination for the refractory and recurrent Hodgkin′s lymphoma(HL) after autologous stem cell transplantation(ASCT). Methods Retrospective analysis was conducted on correlation between maximum SUV and prognoss by PET-CT 1 month after ASCT of 12 HL patients,who were treated by ASCT from November 2007 to March 2013 in the hospital. Results After retro-spective chemotherapy,6 cases were with complete remission,4 cases with partial remission and the other 2 cases were refractory;after transplantation,7 cases were with complete remission,3 cases with partial remission and the other 2 cases were refractory;at the end of follow-up,9 cases were survival(75.0%),and the other 3 cases died due to progression of disease(16.3%). DG-PET positivity was found in 3 patients 1 month after ASCT. After transplantation,the overall survival [83.3%(10/12)] and progression free survival[75.0%(9/12)] of the negative group of PET-CT were obviously higher than those of the positive group,and the differ-ence had statistically significant(P<0.05). Conclusion PET-CT may be deemed as one of prognostic indicators of ASCT.