中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2014年
27期
15-16
,共2页
乳酸脱氢酶%胆碱酯酶%急性白血病
乳痠脫氫酶%膽堿酯酶%急性白血病
유산탈경매%담감지매%급성백혈병
Lactic dehydrogenase%Cholinesterase%Acute leukemia
目的：研究乳酸脱氢酶(lactic dehydrogenase,LDH)及胆碱酯酶(cholinesterase, CHE)在急性白血病中变化的临床意义。方法采用全自动生化分析仪测定急性白血病(acute leukemia, AL)患者于初发/复发组、完全缓解组(complete remission ,CR)、未缓解组(no remission, NR)血清中乳酸脱氢酶(serum lactic dehydrogenase,sLDH)和胆碱酯酶(serum cholinesterase, sCHE)的水平,与正常对照组进行比较。结果 AL患者的sLDH初发/复发组比正常对照组和CR组活性升高,sCHE降低,差异有统计学意义(P<0.001),而CR组与正常对照组比较差异无统计学意义(P>0.05)。NR组sLDH、sCHE与CR组及正常对照组比较差异有统计学意义(sLDH P<0.05、P<0.001, sCHE P<0.05, P<0.001),初发/复发组与NR组比较差异无统计学意义(P>0.05)。结论在AL的初发/复发时sLDH活性升高、sCHE活性降低,有助于急性白血病诊断及病情变化判断。
目的：研究乳痠脫氫酶(lactic dehydrogenase,LDH)及膽堿酯酶(cholinesterase, CHE)在急性白血病中變化的臨床意義。方法採用全自動生化分析儀測定急性白血病(acute leukemia, AL)患者于初髮/複髮組、完全緩解組(complete remission ,CR)、未緩解組(no remission, NR)血清中乳痠脫氫酶(serum lactic dehydrogenase,sLDH)和膽堿酯酶(serum cholinesterase, sCHE)的水平,與正常對照組進行比較。結果 AL患者的sLDH初髮/複髮組比正常對照組和CR組活性升高,sCHE降低,差異有統計學意義(P<0.001),而CR組與正常對照組比較差異無統計學意義(P>0.05)。NR組sLDH、sCHE與CR組及正常對照組比較差異有統計學意義(sLDH P<0.05、P<0.001, sCHE P<0.05, P<0.001),初髮/複髮組與NR組比較差異無統計學意義(P>0.05)。結論在AL的初髮/複髮時sLDH活性升高、sCHE活性降低,有助于急性白血病診斷及病情變化判斷。
목적：연구유산탈경매(lactic dehydrogenase,LDH)급담감지매(cholinesterase, CHE)재급성백혈병중변화적림상의의。방법채용전자동생화분석의측정급성백혈병(acute leukemia, AL)환자우초발/복발조、완전완해조(complete remission ,CR)、미완해조(no remission, NR)혈청중유산탈경매(serum lactic dehydrogenase,sLDH)화담감지매(serum cholinesterase, sCHE)적수평,여정상대조조진행비교。결과 AL환자적sLDH초발/복발조비정상대조조화CR조활성승고,sCHE강저,차이유통계학의의(P<0.001),이CR조여정상대조조비교차이무통계학의의(P>0.05)。NR조sLDH、sCHE여CR조급정상대조조비교차이유통계학의의(sLDH P<0.05、P<0.001, sCHE P<0.05, P<0.001),초발/복발조여NR조비교차이무통계학의의(P>0.05)。결론재AL적초발/복발시sLDH활성승고、sCHE활성강저,유조우급성백혈병진단급병정변화판단。
Objective To study the clinical significance of changes of lactic dehydrogenase (LDH) and cholinesterase (CHE) in acute leukemia (AL). Methods Full automation biochemist analyzer was applied to detect the levels of serum lactic dehydrogenase (sLDH) and serum cholinesterase (sCHE) in acute leukemia primary/recurrence group, complete remission (CR) group and no remission (NR) group, and was compared with control group. Results The sLDH levels of Al patients were increased and sCHE levels were decreased in the primary/recurrence group, compared with the control group and CR group The differences were statistically significant (P<0.001). There was no statistical significance in the difference between CR group and control group (P>0.05). There were statistical significance of the serum levels of sLDH and sCHE in NR group, compared with the control group and CR group (sLDH P<0.05, P<0.001, sCHE P<0.05, P<0.001). There was no statistical significance in the difference between the primary/recurrence group and the NR group (P>0.05). Conclusion The increased level of sLDH and decreased level of sCHE in patients with primary/recurrence AL are helpful in diagnosing and analyzing the severity and change of acute leukemia.
