中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2014年
27期
3-4
,共2页
难治性抑郁症%奥氮平%认知功能
難治性抑鬱癥%奧氮平%認知功能
난치성억욱증%오담평%인지공능
Treatment-refractory depression%Olanzapine%Cognition function
目的：观察奥氮平对难治性抑郁症的疗效及认知功能的影响。方法72例难治性抑郁症患者采用入院顺序分层随机法分为研究组(奥氮平+帕罗西汀)和对照组(帕罗西汀)，在治疗前、治疗后4、8、12周末分别用汉密尔顿抑郁量表(HAMD)、副反应量表(TESS)评定疗效和副作用，韦氏记忆量表(WMS)评定治疗前后患者认知功能的改变。结果治疗12周后，研究组的WMS的再认、联想及记忆商(MQ)为：(9.9±2.7)分、(10.8±2.5)分、(103.2±12.7)分；对照组分别为(8.9±2.5)分、(8.8±2.4)分、(91.7±12.6)分，两组比较差异有统计学意义(P<0.05)。研究组HAMD评分与治疗前比较明显降低，且显著低于对照组(P<0.05)。治疗后4、8、12周末TESS评分，两组比较差异无统计学意义(P>0.05)。结论奥氮平对难治性抑郁症的疗效确切，安全性高，对认知功能的改善彻底。
目的：觀察奧氮平對難治性抑鬱癥的療效及認知功能的影響。方法72例難治性抑鬱癥患者採用入院順序分層隨機法分為研究組(奧氮平+帕囉西汀)和對照組(帕囉西汀)，在治療前、治療後4、8、12週末分彆用漢密爾頓抑鬱量錶(HAMD)、副反應量錶(TESS)評定療效和副作用，韋氏記憶量錶(WMS)評定治療前後患者認知功能的改變。結果治療12週後，研究組的WMS的再認、聯想及記憶商(MQ)為：(9.9±2.7)分、(10.8±2.5)分、(103.2±12.7)分；對照組分彆為(8.9±2.5)分、(8.8±2.4)分、(91.7±12.6)分，兩組比較差異有統計學意義(P<0.05)。研究組HAMD評分與治療前比較明顯降低，且顯著低于對照組(P<0.05)。治療後4、8、12週末TESS評分，兩組比較差異無統計學意義(P>0.05)。結論奧氮平對難治性抑鬱癥的療效確切，安全性高，對認知功能的改善徹底。
목적：관찰오담평대난치성억욱증적료효급인지공능적영향。방법72례난치성억욱증환자채용입원순서분층수궤법분위연구조(오담평+파라서정)화대조조(파라서정)，재치료전、치료후4、8、12주말분별용한밀이돈억욱량표(HAMD)、부반응량표(TESS)평정료효화부작용，위씨기억량표(WMS)평정치료전후환자인지공능적개변。결과치료12주후，연구조적WMS적재인、련상급기억상(MQ)위：(9.9±2.7)분、(10.8±2.5)분、(103.2±12.7)분；대조조분별위(8.9±2.5)분、(8.8±2.4)분、(91.7±12.6)분，량조비교차이유통계학의의(P<0.05)。연구조HAMD평분여치료전비교명현강저，차현저저우대조조(P<0.05)。치료후4、8、12주말TESS평분，량조비교차이무통계학의의(P>0.05)。결론오담평대난치성억욱증적료효학절，안전성고，대인지공능적개선철저。
Objective To observe the influence of olanzapine on curative effect of treatment-refractory depression and cognition function. Methods According to hospital stratified random sequence, 72 cases of treatment-redfractory depression were randomly divided into study group (olanzapine and paroxetine) and control group (paroxetine). At the time before treatment and 4 weeks, 8 weeks, and 12 weeks after treatment, Hamilton Depression Scale (HAMD) and Treatment Emergent Symptom Scale (TESS) were used to evaluate curative effects and side effects, and Wechsler Memory Scale (WMS) was used to evaluate change of cognition function. Results 12 weeks after treatment, the WMS recognition, association and memory quotient (MQ) in control group were (9.9±2.7)points, (10.8±2.5)points, and (103.2±12.7)points, and those of study group were (8.9±2.5) points, (8.8±2.4)points, and (91.7±12.6)points. The difference between the two groups was statisitical significant (P<0.05). HAMD score of the study group decreased obviously after treatment, and it was lower than that of the control group. The scores of TESS after 4, 8, and 12weeks of treatment of the two groups were not statistically significant (P>0.05). Conclusion Olanzapine is effective in the treatment of treatmene-refractory depression with high safety, and its improvement for cognition function is thoroughly.
