CAJ | 학술논문

目的：研究五磨饮治疗脾虚气滞型功能性消化不良的机制。方法选取广州中医药大学附属清远中医院2013年2~12月收治的脾虚气滞型功能性消化不良患者120例，按就诊先后顺序分为治疗组和对照组，各60例，治疗组给予五磨饮中药配方颗粒，对照组给予多潘立酮治疗，两组疗程均为4周。观察临床疗效，检测患者胃动素及胃泌素含量。结果治疗组和对照组总有效率分别为93.3%和83.3%，差异有统计学意义(P<0.05)；治疗组患者血浆胃动素[(376.5±92.8)pg/mL]和胃泌素[(58.8±13.9)pg/mL]含量显著升高(P<0.05)；对照组患者血浆胃动素[(356.7±85.4)pg/mL]含量显著升高(P<0.05)，有升高血清胃泌素[(48.7±12.4)pg/mL]含量的趋势，但差异无统计学意义(P>0.05)。结论五磨饮能够有效治疗脾虚气滞型功能性消化不良，促进胃动素和胃泌素分泌可能是其作用机制之一。
목적：연구오마음치료비허기체형공능성소화불량적궤제。방법선취엄주중의약대학부속청원중의원2013년2~12월수치적비허기체형공능성소화불량환자120례，안취진선후순서분위치료조화대조조，각60례，치료조급여오마음중약배방과립，대조조급여다반립동치료，량조료정균위4주。관찰림상료효，검측환자위동소급위비소함량。결과치료조화대조조총유효솔분별위93.3%화83.3%，차이유통계학의의(P<0.05)；치료조환자혈장위동소[(376.5±92.8)pg/mL]화위비소[(58.8±13.9)pg/mL]함량현저승고(P<0.05)；대조조환자혈장위동소[(356.7±85.4)pg/mL]함량현저승고(P<0.05)，유승고혈청위비소[(48.7±12.4)pg/mL]함량적추세，단차이무통계학의의(P>0.05)。결론오마음능구유효치료비허기체형공능성소화불량，촉진위동소화위비소분비가능시기작용궤제지일。
Objective To study the mechanism of Wumo Decoction in treating functional dyspepsia of spleen deficiency and qistagnation. Methods 120 patients with functional dyspepsia of spleen deficiency and qi stagnation in Qingyuan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine from February to December 2013 were divided into treatment group and control group according to the order of seeing doc-tors, with 60 cases in each group. The treatment group was administered with Wumo Decoction, control group was ad-ministered with Domperidone, three times before meal each day. Both groups were under treatment for four weeks. The clinical effect was observed, the contents of motilin (MTL) and gastrin (GAS) were determined. Results The total effec-tive rates in treatment group and control group were 93.3% and 83.3% respectively, the difference was statistically sig-nificant (P< 0.05); the contents of MTL [(376.5±92.8) pg/mL] and GAS [(58.8±13.9) pg/mL] in treatment group were increased significantly (P<0.05);the content of MTL [(356.7±85.4) pg/mL] in control group was increased significantly (P<0.05);the content of GAS [(48.7±12.4) pg/mL] in control group was increased, but there was no statistically signif-icant difference (P> 0.05). Conclusion Wumo Decoction can relieve clinical symptoms significantly of patients with functional dyspepsia of spleen deficiency and qi stagnation, the mechanism may be related to elevating the level of GAS and MTL.