中国医药导报
中國醫藥導報
중국의약도보
CHINA MEDICAL HERALD
2014年
27期
53-57
,共5页
何丰华%李秋梅%刘毓姿%梁莉婕
何豐華%李鞦梅%劉毓姿%樑莉婕
하봉화%리추매%류육자%량리첩
糖尿病周围神经病变%复元活血汤%神经传导速度
糖尿病週圍神經病變%複元活血湯%神經傳導速度
당뇨병주위신경병변%복원활혈탕%신경전도속도
Diabetic peripheral neuropathy%Fuyuanhuoxue Decoction%Nerve conduction velocity
目的：观察中药复元活血汤治疗糖尿病周围神经病变的临床效果。方法将2010年10月~2014年1月大连市中心医院收治的60例糖尿病周围神经病变的患者随机分为两组。治疗组(30例)应用复元活血汤内服进行治疗；对照组(30例)给予甲钴胺500 mg，1次/d，肌内注射，维生素B110 mg，3次/d，口服。两组同时控制饮食，适量运动，口服降糖药、胰岛素治疗，治疗12周后观察疗效、空腹血糖、糖化血红蛋白(HbA1c)、正中神经、腓神经传导速度变化。结果治疗组，显效19例，有效6例，无效5例，总有效率为83.3%；对照组，显效9例，有效9例，无效12例，总有效率为60.0%，治疗组临床疗效明显优于对照组，差异有高度统计学意义(P<0.01)。治疗后两组空腹血糖与HbA1c均明显下降，差异均有统计学意义(P<0.05)。治疗后两组正中运动神经、感觉神经和腓总神经神经传导速度均较治疗前增快，差异均有统计学意义(P<0.01或P<0.05)；两组间比较，治疗组正中运动神经、感觉神经明显优于对照组，差异均有高度统计学意义(P<0.01)。结论复元活血汤治疗糖尿病周围神经病变具有疗效好、安全性好、患者顺应性强的优点，值得临床推广。
目的：觀察中藥複元活血湯治療糖尿病週圍神經病變的臨床效果。方法將2010年10月~2014年1月大連市中心醫院收治的60例糖尿病週圍神經病變的患者隨機分為兩組。治療組(30例)應用複元活血湯內服進行治療；對照組(30例)給予甲鈷胺500 mg，1次/d，肌內註射，維生素B110 mg，3次/d，口服。兩組同時控製飲食，適量運動，口服降糖藥、胰島素治療，治療12週後觀察療效、空腹血糖、糖化血紅蛋白(HbA1c)、正中神經、腓神經傳導速度變化。結果治療組，顯效19例，有效6例，無效5例，總有效率為83.3%；對照組，顯效9例，有效9例，無效12例，總有效率為60.0%，治療組臨床療效明顯優于對照組，差異有高度統計學意義(P<0.01)。治療後兩組空腹血糖與HbA1c均明顯下降，差異均有統計學意義(P<0.05)。治療後兩組正中運動神經、感覺神經和腓總神經神經傳導速度均較治療前增快，差異均有統計學意義(P<0.01或P<0.05)；兩組間比較，治療組正中運動神經、感覺神經明顯優于對照組，差異均有高度統計學意義(P<0.01)。結論複元活血湯治療糖尿病週圍神經病變具有療效好、安全性好、患者順應性彊的優點，值得臨床推廣。
목적：관찰중약복원활혈탕치료당뇨병주위신경병변적림상효과。방법장2010년10월~2014년1월대련시중심의원수치적60례당뇨병주위신경병변적환자수궤분위량조。치료조(30례)응용복원활혈탕내복진행치료；대조조(30례)급여갑고알500 mg，1차/d，기내주사，유생소B110 mg，3차/d，구복。량조동시공제음식，괄량운동，구복강당약、이도소치료，치료12주후관찰료효、공복혈당、당화혈홍단백(HbA1c)、정중신경、비신경전도속도변화。결과치료조，현효19례，유효6례，무효5례，총유효솔위83.3%；대조조，현효9례，유효9례，무효12례，총유효솔위60.0%，치료조림상료효명현우우대조조，차이유고도통계학의의(P<0.01)。치료후량조공복혈당여HbA1c균명현하강，차이균유통계학의의(P<0.05)。치료후량조정중운동신경、감각신경화비총신경신경전도속도균교치료전증쾌，차이균유통계학의의(P<0.01혹P<0.05)；량조간비교，치료조정중운동신경、감각신경명현우우대조조，차이균유고도통계학의의(P<0.01)。결론복원활혈탕치료당뇨병주위신경병변구유료효호、안전성호、환자순응성강적우점，치득림상추엄。
Objective To observe the clinical curative effect of traditional Chinese medicine Fuyuanhuoxue Decoction in treating for diabetic peripheral neuropathy. Methods From October 2010 to January 2014, at outpatient of the Cen-tral Hospital of Dalian City, 60 patients with diabetic peripheral neuropathy were selected and randomly divided into two groups, the treatment group (30 cases) were treated with Fuyuanhuoxue Decoction, the control group (30 cases) were treated with Mecobalamin 500 mg, 1 time/d, intramuscular injection, vitamin B1 10 mg, 3 times/d, oral. Two groups at the same time were demand controlling diet, exercise, oral hypoglycemic agents, insulin therapy. After 12 weeks of treat-ment, the curative effect, fasting blood glucose, glycosylated hemoglobin (HbA1c), the median nerve, peroneal nerve con-duction velocity were observed. Results Treatment group, 19 cases were marked effect, 6 cases were effective, 5 cases were invalid, total effective rate was 83.3%; control group, 9 cases were marked effect, 9 cases were effective, 12 cases were ineffective, the total effective rate was 60.0%, the clinical effect of treatment group was better than that of control group, the difference was statistically significant (P<0.01). After the treatment, fasting blood glucose and HbA1c of two groups were decreased than those before the treatment, the differences were statistically significant (P<0.05). After the treatment, nerve conduction velocity of median nerve and nervus peroneus communis were faster than those before treatment, the differences were statistically significant (P<0.01 or P<0.05);and median nerve of treatment group were better than those of control group, the differences were statistically significant (P<0.01). Conclusion Chinese medicine Fuyuanhuoxue Decoction in treating diabetic periphera neuropathy has advantages of good effect, good security, strong patient compliance, and it is worth of clinical promotion.
