CAJ | 학술논문

目的：探讨心型脂肪酸结合蛋白(H-FABP)联合肌钙蛋白Ⅰ(cTnⅠ)对脑卒中继发性肺栓塞患者早期诊断及判断预后的价值。方法选取2011年1月~2014年4月北京市通州区潞河医院收治的150例脑卒中继发性肺栓塞患者(研究组)及单纯脑卒中患者150例(对照组)。检测并比较治疗前两组及研究组治疗前后H-FABP、cTnⅠ水平。结果治疗前研究组H-FABP [(9.52±2.67)μg/L]及cTnⅠ[(0.15±0.09)μg/L]水平明显高于对照组[(3.87±2.96)、(0.05±0.03)μg/L]，差异均有统计学意义(P<0.05)；治疗后研究组患者血浆H-FABP、cTnⅠ水平分别为(5.51±1.97)、(0.08±0.03)μg/L，较治疗前明显降低，差异均有统计学意义(P<0.05)。结论脑卒中继发性肺栓塞患者血浆H-FABP及cTnⅠ浓度明显升高，两指标联合有助于脑卒中继发性肺栓塞的早期诊断和短期预后情况的评估。
목적：탐토심형지방산결합단백(H-FABP)연합기개단백Ⅰ(cTnⅠ)대뇌졸중계발성폐전새환자조기진단급판단예후적개치。방법선취2011년1월~2014년4월북경시통주구로하의원수치적150례뇌졸중계발성폐전새환자(연구조)급단순뇌졸중환자150례(대조조)。검측병비교치료전량조급연구조치료전후H-FABP、cTnⅠ수평。결과치료전연구조H-FABP [(9.52±2.67)μg/L]급cTnⅠ[(0.15±0.09)μg/L]수평명현고우대조조[(3.87±2.96)、(0.05±0.03)μg/L]，차이균유통계학의의(P<0.05)；치료후연구조환자혈장H-FABP、cTnⅠ수평분별위(5.51±1.97)、(0.08±0.03)μg/L，교치료전명현강저，차이균유통계학의의(P<0.05)。결론뇌졸중계발성폐전새환자혈장H-FABP급cTnⅠ농도명현승고，량지표연합유조우뇌졸중계발성폐전새적조기진단화단기예후정황적평고。
Objective To investigate the diagnosis and prognostic value of heart-type fatty acid binding protein com-bined cardiac troponin Ⅰ in stroke-associated pulmonary embolism patients. Methods 150 patients with stroke-asso-ciated pulmonary embolism (study group) and 150 patients of stroke without pulmonary embolism (control group) from January 2011 to April 2014 in Luhe Hospital of Tongzhou District in Beijing City were selected in this study. The H-FABP and cardiac troponin Ⅰ of patients in two groups before treatment and those of the study group after treatment were detected and compared. Results The levels of plasma H-FABP and cardiac troponin Ⅰ of patients before treat-ment in study group [(9.52±2.67), (0.15±0.09) μg/L ] were higher than those of the control group [(3.87±2.96), (0.05±0.03) μg/L], the differences were statistically significant (P<0.05).After treatment, the levels of plasma H-FABP and cardiac troponinⅠ in study group [(5.51±1.97), (0.08±0.03) μg/L] were decreased than pretreatment, the differences were statistically significant (P<0.05). Conclusion The level of H-FABP and cardiac troponinⅠ increasing obviously in stroke-associated pulmonary embolism, and the detection of the two indexs can be helpful for the disease diagnosis and the access of short-time prognosis.