CAJ | 학술논문

目的：探讨血清S-100蛋白、神经元特异性烯醇化酶(NSE)水平与早产儿脑损伤的关系。方法94例符合条件的早产儿随机分为有脑损伤的实验组(49例)和无脑损伤的对照组(45例)，采用ELISA法分别在早产儿出生后24 h内及7 d后对比检测实验组和对照组早产儿血清的S-100蛋白、NSE水平。结果实验组出生后24 h内及7 d后其血清S-100蛋白、NSE水平均明显高于对照组，差异具有统计学意义(P<0.05)。脑损伤患儿的血清S-100蛋白及NSE改变明显早于影像学改变。结论血清S-100蛋白、NSE水平能较早的反映早产儿脑损伤及其严重程度，对早产儿脑损伤的早期诊断有较高的价值。
목적：탐토혈청S-100단백、신경원특이성희순화매(NSE)수평여조산인뇌손상적관계。방법94례부합조건적조산인수궤분위유뇌손상적실험조(49례)화무뇌손상적대조조(45례)，채용ELISA법분별재조산인출생후24 h내급7 d후대비검측실험조화대조조조산인혈청적S-100단백、NSE수평。결과실험조출생후24 h내급7 d후기혈청S-100단백、NSE수평균명현고우대조조，차이구유통계학의의(P<0.05)。뇌손상환인적혈청S-100단백급NSE개변명현조우영상학개변。결론혈청S-100단백、NSE수평능교조적반영조산인뇌손상급기엄중정도，대조산인뇌손상적조기진단유교고적개치。
Objective To investigate the relation between serum S-100 protein, neuron specific enolase (NSE) and cerebral injury of preterm infant. Methods A total of 94 preterm infants were randomly divided into experimental group with brain injury (n=49) and control group without brain injury (n=45). ELISA method was used to detect the serum S-100 protein and NSE levels of experimental group and control group in postnatal 24 h and 7 d. Results The serum S-100 protein and NSE levels of the experimental group were obviously higher than those of the control group in postnatal 24 h and 7 d. The difference had statistical significance (P<0.05). The changes of serum S-100 protein and NSE in cerebral injury infants were significantly earlier than the imaging change. Conclusion Levels of serum S-100 protein and NSE can reflect the extent and severity of cerebral injury in preterm infant. They have high value for the early diagnosis of cerebral injury in preterm infant.