CAJ | 학술논문

目的：探讨老年非小细胞肺癌患者生存状况及预后相关因素，为临床治疗提供参考依据。方法回顾性分析87例老年非小细胞肺癌患者的临床资料，利用Kaplan-Meier法进行生存率统计，并进行Log-rank时序检验，利用比例风险模型(Cox模型)进行多因素分析，筛选出相关因素。结果87例老年非小细胞肺癌患者1、2、4年生存率分别为52.9%、26.2%、2.8%，中位生存时间为14个月。单因素分析结果显示，患者的KPS评分、TNM分期、靶向治疗、治疗方式对生存期有影响(P<0.05)，多因素分析显示KPS评分、治疗方式是预后的独立因素(P<0.05)。结论 KPS≥70分、能够耐受综合治疗的老年患者应当积极治疗，这些患者的生存期较长，是潜在的治疗获益者。
목적：탐토노년비소세포폐암환자생존상황급예후상관인소，위림상치료제공삼고의거。방법회고성분석87례노년비소세포폐암환자적림상자료，이용Kaplan-Meier법진행생존솔통계，병진행Log-rank시서검험，이용비례풍험모형(Cox모형)진행다인소분석，사선출상관인소。결과87례노년비소세포폐암환자1、2、4년생존솔분별위52.9%、26.2%、2.8%，중위생존시간위14개월。단인소분석결과현시，환자적KPS평분、TNM분기、파향치료、치료방식대생존기유영향(P<0.05)，다인소분석현시KPS평분、치료방식시예후적독립인소(P<0.05)。결론 KPS≥70분、능구내수종합치료적노년환자응당적겁치료，저사환자적생존기교장，시잠재적치료획익자。
Objective To study the survival situation and prognostic factors of the elderly patients with non-small cell lung cancer (NSCLC), in order to provide references for clinical treatment. Methods The clinical data of 87 elderly NSCLC patients were retrospectively reviewed. Kaplan-Meier method and log-rank test were used for survival rate analysis, and Cox’s proportion risk model was used for multivariate analysis. Relevant factors were selected after analysis. Results Among all the 87 patients, the survival rates of 1-year, 2-year and 4-year were 52.9%, 26.2%and 2.8%, and the median survival time was 14 months. The univariate analysis showed that patients’karnofsky performance status (KPS) score, Tumor Node Metastasis (TNM) stage, target therapy and the therapy mode were related to survival period (P<0.05). The multivariate analysis indicated that patients’KPS score and the therapy mode were closely related to their prognosis (P<0.05). Conclusion The elderly patients with KPS score≥70 and bearing comprehensive treatment have longer survival time and they can benefit from treatments.