CAJ | 학술논문

目的探讨艾司西酞普兰合并身心语法程序(NLP)治疗对躯体形式障碍患者认知功能的影响.方法 120例躯体形式障碍患者被随机分为艾司西酞普兰治疗组(单药组)和艾司西酞普兰与NLP合并治疗组(合并组),每组60例,疗程6周,在基线及治疗6周后分别使用90项症状清单和功能大体评定量表评估疗效,使用瑞文标准推理测验、成人韦氏智力测验中的数字广度与数字符号测验评定认知功能,并同时进行事件相关电位P300检测.正常健康者60例作为对照.结果躯体形式障碍患者的瑞文分数、数字广度、数字符号得分均低于对照组(P＜0.01),N1、P3潜伏期长于对照组(P＜0.01或＜0.05),N1N2、N2P2、P2P3波幅小于对照组(均P=0.00)；治疗后单药组和合并组两组的瑞文分数[(91.25±14.87)分,(95.60± 19.95)分]、数字广度得分[(11.98 ±1.89)分,(10.90土2.76)分]、数字符号得分[(11.71 ±2.89)分,(11.92±2.90)分]、N2P2波幅[(11.32±6.67) μV,(13.39±9.31) μV]、P2P3波幅[(9.04±6.14) μV,(9.51±7.17)μV]增加、N2潜伏期[(240.60±41.41) ms,(238.31±41.47) ms]延长,N1潜伏期缩短(P＜0.05或0.01)；单药组与合并组治疗前后比较,在数字广度、P2潜伏期、N1N2、N2P2、P2P3波幅方面差异有统计学意义(P＜0.05或0.01).结论艾司西酞普兰单药治疗及艾司西酞普兰合并NLP治疗对躯体形式障碍患者的认知功能均有改善作用,其中合并治疗的优势更加突出.
목적 탐토애사서태보란합병신심어법정서(NLP)치료대구체형식장애환자인지공능적영향.방법 120례구체형식장애환자피수궤분위애사서태보란치료조(단약조)화애사서태보란여NLP합병치료조(합병조),매조60례,료정6주,재기선급치료6주후분별사용90항증상청단화공능대체평정량표평고료효,사용서문표준추리측험、성인위씨지력측험중적수자엄도여수자부호측험평정인지공능,병동시진행사건상관전위P300검측.정상건강자60례작위대조.결과 구체형식장애환자적서문분수、수자엄도、수자부호득분균저우대조조(P＜0.01),N1、P3잠복기장우대조조(P＜0.01혹＜0.05),N1N2、N2P2、P2P3파폭소우대조조(균P=0.00)；치료후단약조화합병조량조적서문분수[(91.25±14.87)분,(95.60± 19.95)분]、수자엄도득분[(11.98 ±1.89)분,(10.90토2.76)분]、수자부호득분[(11.71 ±2.89)분,(11.92±2.90)분]、N2P2파폭[(11.32±6.67) μV,(13.39±9.31) μV]、P2P3파폭[(9.04±6.14) μV,(9.51±7.17)μV]증가、N2잠복기[(240.60±41.41) ms,(238.31±41.47) ms]연장,N1잠복기축단(P＜0.05혹0.01)；단약조여합병조치료전후비교,재수자엄도、P2잠복기、N1N2、N2P2、P2P3파폭방면차이유통계학의의(P＜0.05혹0.01).결론 애사서태보란단약치료급애사서태보란합병NLP치료대구체형식장애환자적인지공능균유개선작용,기중합병치료적우세경가돌출.
Objective To investigate the effect of escitalopram combined neuro-linguistic programming treatment(NLP) on cognitive function in patients with somatoform disorders.Methods 120 cases with somatoform disorders were randomly divided into the escitalopram monotherapy group and escitalopram with NLP combined group,with 60 cases in each group for six weeks.At baseline and after six weeks for treatment,it was respectively assessed that the efficacy using Symptom Checklist 90 and Global Assessment Function,and cognitive function using the Raven Standard Progressive Matrices Test,digit span and digit symbol tests in Adult Wechsler Intelligence Test,while event related potentials P300 were detected.60 cases normal healthy adults as controls.Results Compared with the control group,the Raven scores,digit span,digit symbol scores were lower (P ＜0.01),N1,P3 latent periods were longer (P ＜ 0.01 or ＜ 0.05),N1N2,N2P2,P2P3 amplitudes were less(P =0.00) in patients with somatoform disorders.After treatment,Raven scores(91.25 ± 14.87,95.60 ± 19.95),digit span scores (11.98 ± 1.89,10.90 ± 2.76),digit symbol scores (11.71 ± 2.89,11.92 ± 2.90),N2P2 amplitudes ((11.32 ± 6.67) μV,(13.39 ± 9.31) μV),P2P3 amplitudes ((9.04 ± 6.14) μV,(9.51 ± 7.17) μV) increased,N2 latent periods ((240.60 ± 41.41) ms,(238.31 ± 41.47) ms) prolonged,N1 latent periods shortened (P ＜ 0.05 or 0.01) in the monotherapy group and the combined group.The digit span,P2 latent periods,N1N2,N2P2,P2P3 amplitudes had statistically significant differences between monotherapy group and combined group after treatment(P ＜ 0.05 or 0.01).Conclusion Both escitalopram monotherapy and escitalopram combined NLP have improved cognitive function in patients with somatoform disorders,but combined therapy has more prominent advantage.