CAJ | 학술논문

淋球菌是引起淋病的病原菌,如不及时治疗可以引起严重的并发症.为了更好的研究淋球菌的流行特点、遗传学、免疫学等科学问题,有必要研究淋球菌的分型方法.目前淋球菌分型可分为传统分型和基因分型,其中后者应用较多.在基因分型中,又可分为凝胶电泳DNA条带分型和序列分型.应用除多位点可变数串联重复序列分型以外的凝胶电泳DNA条带分型方法所得到的结果较主观,实验室之间的结果不具有可比性.
림구균시인기임병적병원균,여불급시치료가이인기엄중적병발증.위료경호적연구림구균적류행특점、유전학、면역학등과학문제,유필요연구림구균적분형방법.목전림구균분형가분위전통분형화기인분형,기중후자응용교다.재기인분형중,우가분위응효전영DNA조대분형화서렬분형.응용제다위점가변수천련중복서렬분형이외적응효전영DNA조대분형방법소득도적결과교주관,실험실지간적결과불구유가비성.
Neisseria gonorrhoeae (NG) is the pathogen of gonococcus that can cause serious complications without timely treatment.It is necessary to optimize genotyping methods for further researches into the epidemiology,genetics,and immunology of NG.At present,the genotyping methods are divided into two groups,i.e.traditional,non-DNA-based phenotypic typing methods and DNA-based typing methods.DNA-based typing methods are applied more common,and include gel-based methods and DNA sequence-based methods.The typing results of most gel-based typing methods (except the multiple-locus variable number tandem repeat analysis (MLVA)) are subjective and incomparable between laboratories.