CAJ | 학술논문

目的：观察神经节苷脂（GM1）对脑梗死急性期认知功能障碍的改善作用，评估其临床疗效和安全性。方法选择2009年1月至2013年1月上海市第一人民医院宝山分院收治的41例脑梗死急性期认知功能障碍患者，随机分为观察组20例，对照组21例，所有病例均采用神经内科急性脑梗死常规治疗方案，观察组在此基础上加用 GM1治疗。治疗前后行简易智能精神状态检查量表(MMSE)，观察认知功能的改善程度。结果两组病例治疗后 MMSE 评分较治疗前均明显好转(P<0.05)，但观察组改善更为明显。观察组治疗后与对照组治疗后 MMSE 评分比较差异有统计学意义。结论在急性脑梗死常规治疗基础上，应用 GM1能明显改善急性脑梗死患者的认知功能障碍及生活质量。
목적：관찰신경절감지（GM1）대뇌경사급성기인지공능장애적개선작용，평고기림상료효화안전성。방법선택2009년1월지2013년1월상해시제일인민의원보산분원수치적41례뇌경사급성기인지공능장애환자，수궤분위관찰조20례，대조조21례，소유병례균채용신경내과급성뇌경사상규치료방안，관찰조재차기출상가용 GM1치료。치료전후행간역지능정신상태검사량표(MMSE)，관찰인지공능적개선정도。결과량조병례치료후 MMSE 평분교치료전균명현호전(P<0.05)，단관찰조개선경위명현。관찰조치료후여대조조치료후 MMSE 평분비교차이유통계학의의。결론재급성뇌경사상규치료기출상，응용 GM1능명현개선급성뇌경사환자적인지공능장애급생활질량。
Objective Inordertoinvestigatethefunctionofganglioside(GM1)onacutephasein cerebral infarction of cognitive impairment, to evaluate the clinical efficacy and safety, we will carry out the following experiment. Methods In a sample of 41 groups on acute phase in cerebral infarction of cognitive impairment , we divide it randomly into two large groups, one for observation group which includes 20 cases, the other is control group, including 21 cases. All patients were treated with conventional treatment of acute cerebral infarction neurology program. On the basis of conventional treatment, GM1 treatment is also used in the observation group. With the help of intelligent Mental State Examination (MMSE) before and after the treatment, we can observe the improvement of cognitive functions. Results After treatment, two large groups on the score of MMSE were both improved compared with without treatment (P<0.05). However, observation group improved more in the comparison of control group. There is statistical significance on difference between observation group and control group in terms of MMSE score after treatment. Conclusion On the basis of conventional treatment of acute cerebral infarction, applying GM1 can apparently improve both cognitive impairment and life quality of patients with acute cerebral infarction.