CAJ | 학술논문

目的：研究竹节参总皂苷（TSPJ）对脑出血大鼠脑损伤不同时间段的影响。方法采用胶原酶法制备脑出血动物模型，将48只大鼠随机分为假手术组、模型组、TSPJ低、高剂量组共4组，每组12只；造模后6h灌胃给药，每12h 1次，于造模后12、72h测各组大鼠脑组织含水量，超氧化物歧化酶、丙二醛含量，IL-6、TNF-α水平。结果与模型组比较，72 h高剂量TSPJ组脑组织含水量减少，超氧化物歧化酶活性增高，丙二醛含量下降， IL-6、TNF-α水平下降，12h时TSPJ高剂量组超氧化物歧化酶活性增高，TNF-α下降；丙二醛、IL-6含量变化不明显。结论TSPJ能减轻出血性脑损伤，对受损脑组织发挥保护作用，且有时间依赖性。
목적：연구죽절삼총조감（TSPJ）대뇌출혈대서뇌손상불동시간단적영향。방법채용효원매법제비뇌출혈동물모형，장48지대서수궤분위가수술조、모형조、TSPJ저、고제량조공4조，매조12지；조모후6h관위급약，매12h 1차，우조모후12、72h측각조대서뇌조직함수량，초양화물기화매、병이철함량，IL-6、TNF-α수평。결과여모형조비교，72 h고제량TSPJ조뇌조직함수량감소，초양화물기화매활성증고，병이철함량하강， IL-6、TNF-α수평하강，12h시TSPJ고제량조초양화물기화매활성증고，TNF-α하강；병이철、IL-6함량변화불명현。결론TSPJ능감경출혈성뇌손상，대수손뇌조직발휘보호작용，차유시간의뢰성。
Objective To study the effect of total saponins from Panax japonicus ( TSPJ) on brain injury in different time of rats after intracerebral hemorrhage ( IHC) .Methods The rat model of IHC was established with collagen.48 rats were randomly divided into sham operation control group ,model group,TSPJ 100mg/kg and 200mg/kg groups.Rats were administrated 6 h after IHC,once every 12 h.Brain water content,SOD ac-tivity and ,MDA,IL-6,TNF-αlevels were determined at 12 h and 72 h after IHC,respectively.Results Compare with model group ,brain water content ,MDA,IL-6 and TNF-αlevels were decreased ,and SOD was increased in TSPJ 200 mg/kg group at 72 h after IHC .At 12 h after modeling , only SOD was increased .Conclusion TSPJ can decrease brain water content and ,MDA,IL-6,TNF-αlevels of ICH rats at 72 h,increase SOD activity,and protect the damaged brain tissue after ICH .