CAJ | 학술논문

目的：探讨慢性束缚应激对大鼠血压和血管内皮功能的影响。方法 SD大鼠随机分为对照组和应激组，每组10只。应激组大鼠每天被置于不能自由活动的固定器内束缚2 h，1次/d，连续21 d，最后一次应激结束后24 h分别测定各组大鼠自发活动、动脉血压、血管张力和血浆一氧化氮（ NO）含量。结果与对照组比较，应激组大鼠自发活动明显减少（P＜0．05），血管收缩压明显升高（P＜0．05），血管舒张功能和血浆NO含量明显下降（P＜0．01或P＜0．05）。结论慢性束缚应激可致血管内皮功能障碍，进而促进高血压等心血管疾病的发生。
목적：탐토만성속박응격대대서혈압화혈관내피공능적영향。방법 SD대서수궤분위대조조화응격조，매조10지。응격조대서매천피치우불능자유활동적고정기내속박2 h，1차/d，련속21 d，최후일차응격결속후24 h분별측정각조대서자발활동、동맥혈압、혈관장력화혈장일양화담（ NO）함량。결과여대조조비교，응격조대서자발활동명현감소（P＜0．05），혈관수축압명현승고（P＜0．05），혈관서장공능화혈장NO함량명현하강（P＜0．01혹P＜0．05）。결론만성속박응격가치혈관내피공능장애，진이촉진고혈압등심혈관질병적발생。
Objective To observe the effects of chronic immobilization stress on blood pressure and vas-cular endothelial function in rats .Methods 20 SD rats were randomly divided into two groups , control group and stress group,10 rats in each group.Rats in the stress group were subjected to immobilization stress 2h/d for 21 d using a restrainer .24 h after the last stress ,rats in the two groups were used to measure the locomotive ac-tivity,the arterial blood pressure,vascular tone and plasma nitric oxide (NO) level,respectively.Results Com-pared with the control group,the locomotive activity of the stress group was markedly decreased (P<0.05), systolic blood pressure was significantly increased (P<0.05),while the vascular diastolic function and the plasma NO level were markedly decreased ( P<0 .01 or P<0 .05 ) .Conclusion Chronic immobilization stress can induce vascular endothelial dysfunction which contributes to the development of hypertension and other car -diovascular diseases .